Ampulla of Vater/duodenal wall spasm diagnosed by antroduodenal manometry

Koussayer, Tarek; Ducker, T. E.; Clench, Mary H.; Mathias, John R.

doi:10.1007/bf02212692

Cited by 19 publications

(8 citation statements)

References 31 publications

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“…There is evidence that SO dysfunction may be part of a generalized motor disorder of the gastrointestinal tract. Small intestinal dysmotility has been seen in association with SO dysfunction (47)(48)(49). In one study (50), patients with irritable bowel syndrome and SO dysfunction demonstrated paradoxical responses to CCK more often than patients with SO dysfunction alone.…”

Section: Mechanism Of So Dysfunctionmentioning

confidence: 99%

Sphincter of Oddi Function and Dysfunction

Toouli

Craig²

2000

Canadian Journal of Gastroenterology

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The sphincter of Oddi (SO) is situated at the junction of the bile and pancreatic ducts where they enter the duodenum, and it serves to regulate the flow of bile and pancreatic juices as well as to prevent the reflux of duodenal contents into the pancreatobiliary system. SO dysfunction relates to either the biliary or pancreatic portions of the sphincter. Distinct clinical syndromes relating to either sphincter segment are recognized. The mechanism of dysfunction remains uncertain, but disruption of neural pathways involved in sphincter function seems likely. SO dysfunction is best diagnosed by manometry, which is able to correctly stratify patient groups and determine therapy. Biliary scintigraphy, which is noninvasive, has shown promise as a screening tool for patients with suspected SO dysfunction. Division of the sphincter is an effective treatment for patients with manometrically proven SO stenosis for either the biliary or pancreatic form of the disorder. Other forms of SO dysfunction may benefit from pharmacotherapy.

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Section: Mechanism Of So Dysfunctionmentioning

confidence: 99%

Sphincter of Oddi Function and Dysfunction

Toouli

Craig²

2000

Canadian Journal of Gastroenterology

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“…These five patients have been investigated for elevated pancreatic enzymes from other causes, including fractionation of the enzymes, macroenzyme evaluations, multiple abdominal CT and sonograms, and in two patients endoscopic ultrasound (EUS) and MRCP, and all have been reported as normal. The only finding in two of them is the report of antroduodenal manometry showing the so-called "ampulla of Vater spasm" in the channel positioned at the second portion of the duodenum [32]. Two other patients with CIPO and suspected mitochondrial cytopathy also have intermittent abdominal pain associated with elevation of pancreatic enzymes.…”

Section: Chronic Intestinal Pseudoobstructionmentioning

confidence: 97%

Sphincter of oddi dysfunction in children

Guelrud

Rodriguez²

2006

Curr Gastroenterol Rep

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Sphincter of Oddi dysfunction (SOD) is a clinical entity caused by a primary motility alteration of either the biliary or the pancreatic sphincter. SOD is a rare condition that has been scarcely reported in children. Most of the reported literature has been in children with idiopathic recurrent pancreatitis. These children are treated endoscopically by dual sphincterotomy of the pancreatic and common duct sphincters. However, the safety and efficacy of sphincter of Oddi manometry and sphincterotomy in the pediatric population await further study.

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“…This can be triggered by the injection or secretion of cholecystokinin. Cholecystokinin triggers propagated contractions within the sphincter that milk bile or pancreatic secretions into the duodenum [14,43]. Hence, the opening occurs by the sphincter itself relaxing with some help from pressurization.…”

Section: Soomentioning

confidence: 99%

A mechanics--based perspective on the function of human sphincters during functional luminal imaging probe manometry

Elisha¹,

Halder²,

Carlson³

et al. 2022

Preprint

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Functional luminal imaging probe (FLIP) is used to measure cross-sectional area (CSA) and pressure at sphincters. It consists of a catheter surrounded by a fluid filled cylindrical bag, closed on both ends. Plotting the pressure-CSA hysteresis of a sphincter during a contraction cycle, which is available through FLIP testing, offers information on its functionality, and can provide diagnostic insights. However, limited work has been done to explain the mechanics of these pressure-CSA loops. This work presents a consolidated picture of pressure-CSA loops of different sphincters. Clinical data reveal that although sphincters have a similar purpose (controlling the flow of liquids and solids by opening and closing), two different pressure-CSA loop patterns emerge: negative slope loop (NSL) and positive slope loop (PSL). We show that the loop type is the result of an interplay between (or lack thereof) two mechanical modes: (i) neurogenic mediated relaxation of the sphincter muscle and (ii) muscle contraction proximal to the sphincter which causes mechanical distention. We conclude that sphincters which only function through mechanism (i) exhibition NSL whereas sphincters which open as a result of both (i) and (ii) display a PSL. This work provides a fundamental mechanical understanding of human sphincters. This can be used to identify normal and abnormal phenotypes for the different sphincters and help in creating physiomarkers based on work calculation.

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Ampulla of Vater/duodenal wall spasm diagnosed by antroduodenal manometry

Cited by 19 publications

References 31 publications

Sphincter of Oddi Function and Dysfunction

Sphincter of Oddi Function and Dysfunction

Sphincter of oddi dysfunction in children

A mechanics--based perspective on the function of human sphincters during functional luminal imaging probe manometry

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