Ampullary carcinosarcoma with osteosarcomatous, small cell neuroendocrine carcinoma and conventional adenocarcinoma components; First report

Rao, Pallavi; Sikora, Sadiq S.; Narayanaswamy, Srikanth; Ghosal, Nandita; Kini, Dinesh

doi:10.1016/j.prp.2016.08.007

Pathology - Research and Practice

2016

DOI: 10.1016/j.prp.2016.08.007

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Ampullary carcinosarcoma with osteosarcomatous, small cell neuroendocrine carcinoma and conventional adenocarcinoma components; First report

Pallavi Rao¹,

Sadiq S. Sikora²,

Srikanth Narayanaswamy³

et al.

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Cited by 6 publications

(2 citation statements)

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“…The frequency of pulmonary carcinosarcomas is 4.0% among sarcomatoid carcinomas of the lung, accounting for only 0.1-0.4% of all lung cancers. 1 Carcinosarcomas with neuroendocrine differentiation are rare and have been reported in the gastrointestinal tract, genitourinary system, [2][3][4][5] and lung. 6,7 Carcinosarcoma is a clonal tumor developed through sarcomatoid changes in the carcinoma via the epithelialmesenchymal transition (EMT).…”

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Pulmonary carcinosarcoma characterized by small round cells with neuroendocrine, myogenic, and chondrogenic differentiation: An extremely rare case

Tamiya

Sato

Tsuta

et al. 2019

Pathology International

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Carcinosarcoma is a clonal tumor developed through sarcomatoid changes in a carcinoma via the epithelial–mesenchymal transition (EMT). Here, we present an extremely rare case of pulmonary carcinosarcoma characterized by components suggesting pluripotency, namely neuroendocrine, myogenic, and chondrogenic differentiation, based on immunohistochemical analysis. A 42‐year‐old Japanese man was admitted to our hospital. Analysis of tumor tissue after right upper lobe lobectomy revealed a transition between carcinomatous and sarcomatous components. Immunohistochemical analysis suggested immortality owing to complete loss of p53 and diffuse expression of p16 in both the carcinomatous and sarcomatous components. There were also scattered cell groups expressing aldehyde dehydrogenase 1 family member A1, SOX2, CD133, and c‐kit, suggesting the possible presence of cancer stem cells. Our findings in this case suggested that the EMT may play a key role in mediating the immortality of tumor cells in carcinosarcoma and facilitating the pluripotency of cancer stem cells.

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confidence: 99%

“…The frequency of pulmonary carcinosarcomas is 4.0% among sarcomatoid carcinomas of the lung, accounting for only 0.1–0.4% of all lung cancers . Carcinosarcomas with neuroendocrine differentiation are rare and have been reported in the gastrointestinal tract, genitourinary system, and lung …”

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confidence: 99%

Pulmonary carcinosarcoma characterized by small round cells with neuroendocrine, myogenic, and chondrogenic differentiation: An extremely rare case

Tamiya

Sato

Tsuta

et al. 2019

Pathology International

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Carcinosarcoma of Vater’s papilla: case report of a rare neoplasm and review of the literature

et al. 2019

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BackgroundCarcinosarcoma is a rare tumor that includes both carcinoma and sarcoma components. It develops commonly in the female reproductive tract, most often in the uterus. However, as there are a small number of similar cases in the English literature, we would like to present a rare case of a carcinosarcoma in Vater’s papilla.Case presentationA 76-year-old female patient was preoperatively diagnosed with a papillary adenocarcinoma in Vater’s papilla by endoscopic biopsy. The patient underwent subtotal stomach-preserving pancreaticoduodenectomy, and postoperative pathological examination diagnosed the carcinosarcoma. The patient received adjuvant chemotherapy with gemcitabine, but multiple liver metastases were found 3 months after the operation. Though chemotherapy with gemcitabine and cisplatin was introduced, she died owing to tumor progression 7 months after the operation.ConclusionBecause carcinosarcoma of Vater’s papilla is a rare disease, a suitable treatment strategy has been unclear. We also present a review of the English literature regarding carcinosarcoma of Vater’s papilla.

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Primary Carcinosarcoma of the Ampulla of Vater: Clinicopathological Analysis and Literature Review

齐¹

2020

ACM

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Ampullary carcinosarcoma with osteosarcomatous, small cell neuroendocrine carcinoma and conventional adenocarcinoma components; First report

Cited by 6 publications

References 18 publications

Pulmonary carcinosarcoma characterized by small round cells with neuroendocrine, myogenic, and chondrogenic differentiation: An extremely rare case

Pulmonary carcinosarcoma characterized by small round cells with neuroendocrine, myogenic, and chondrogenic differentiation: An extremely rare case

Carcinosarcoma of Vater’s papilla: case report of a rare neoplasm and review of the literature

Primary Carcinosarcoma of the Ampulla of Vater: Clinicopathological Analysis and Literature Review

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