Amygdala volumes in mood disorders — Meta-analysis of magnetic resonance volumetry studies

Hájek, Tomáš; Kopeček, Miloslav; Kožený, Jiří; Gunde, Eva; Alda, Martin; Höschl, Cyril

doi:10.1016/j.jad.2008.10.007

Cited by 106 publications

(71 citation statements)

References 51 publications

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“…In our quantitative meta-analysis we find clusters of convergence in bilateral IFG, ACC, bilateral medial and left superior frontal gyrus, subgenual cingulate cortex, left parahippocampal gyrus and left caudate that are in line with these narrative-based meta-analytic studies. Surprisingly we find no convergence in VBM whole-brain studies in amygdala or hippocampus although region of interest based volumetric analysis consistently revealed differences (Hajek et al, 2009;Hamilton, Siemer and Gotlib, 2008).…”

Section: Neural Correlates Of Rumination and Its Relation To Major Decontrasting

confidence: 65%

Why ruminators won't stop: The structural and resting state correlates of rumination and its relation to depression

Kühn¹,

Vanderhasselt²,

Raedt³

et al. 2012

Journal of Affective Disorders

130

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Note: This is an uncorrected version of an author's manuscript accepted for publication. Copyediting, typesetting, and review of the resulting proofs will be undertaken on this manuscript before final publication. During production and pre-press, errors may be discovered that could affect the content. AbstractBackground: Rumination is a good predictor of major depression. The current study explores

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Section: Neural Correlates Of Rumination and Its Relation To Major Decontrasting

confidence: 65%

Why ruminators won't stop: The structural and resting state correlates of rumination and its relation to depression

Kühn¹,

Vanderhasselt²,

Raedt³

et al. 2012

Journal of Affective Disorders

130

View full text Add to dashboard Cite

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“…Furthermore it has been shown that slice thickness does not affect hippocampal volumes (Campbell et al 2004). In keeping with this we, as well as others have previously combined data obtained with a range of slice thicknesses for meta-analytical purposes (Hajek et al 2008(Hajek et al , 2009Kempton et al 2008). Five out of seven volumetric analyses were blinded to the genotype of the participants.…”

Section: Discussionmentioning

confidence: 59%

Reduced hippocampal volumes in healthy carriers of brain-derived neurotrophic factor Val66Met polymorphism: Meta-analysis

Hájek

Kopeček

Höschl

2011

The World Journal of Biological Psychiatry

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Objectives-Converging evidence suggests that the brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism affects brain structure. Yet the majority of studies have shown no effect of this polymorphism on hippocampal volumes, perhaps due to small effect size.Methods-We performed a meta-analysis of studies investigating the association between Val66Met BDNF polymorphism and hippocampal volumes in healthy subjects by combining standardized differences between means (SDM) from individual studies using random effect models. Conclusions-Healthy carriers of BDNF gene Val66Met polymorphism show bilateral hippocampal volume reduction. The effect size was small, but the same direction of effect was seen in all meta-analyzed studies. The association with the BDNF gene Val66Met polymorphism makes hippocampal volume a potential candidate for an endophenotype of disorders presenting with reduced hippocampal volumes. Results-Data

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“…If mesiotemporal volumes are an endophenotype for BD, then affected offspring should show the largest differences relative to control subjects, with intermediate volumes among unaffected patients. As most studies reported lack of hippocampal volume changes 21 and decreased amygdala volumes in young patients with BD, 20 we expected to find comparable hippocampal and decreased amygdala volumes both in affected and in unaffected offspring of patients with BD relative to control subjects.…”

mentioning

confidence: 83%

Amygdala and Hippocampal Volumes in Relatives of Patients with Bipolar Disorder: A High—Risk Study

et al. 2009

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M esiotemporal structures including hippocampus and amygdala have been implicated in the pathophysiology of BD by converging evidence from structural, 1 functional neuroimaging, 2 neuropathological, 3 and neurocognitive 4 studies. Structural neuroimaging findings regarding the amygdala are markedly heterogeneous, with findings of decreased, 5-8 unchanged, 9-13 as well as increased 14-18 amygdala volumes in patients with BD relative to control subjects. Similarly, the literature regarding hippocampal volumes is inconsistent with most studies reporting lack of hippocampal volume changes, 7,14-16 but also with findings of decreased 10 as well as increased 5,19 hippocampal volumes in patients with BD. These discrepancies likely reflect clinical and treatment heterogeneity. 20,21

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Amygdala volumes in mood disorders — Meta-analysis of magnetic resonance volumetry studies

Cited by 106 publications

References 51 publications

Why ruminators won't stop: The structural and resting state correlates of rumination and its relation to depression

Why ruminators won't stop: The structural and resting state correlates of rumination and its relation to depression

Reduced hippocampal volumes in healthy carriers of brain-derived neurotrophic factor Val66Met polymorphism: Meta-analysis

Amygdala and Hippocampal Volumes in Relatives of Patients with Bipolar Disorder: A High—Risk Study

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