Amygdalar kindling is associated with elevated zinc concentration in the cortex and hippocampus of rats

Kasarskis, Edward J.; Forrester, Tina M.; Slevin, John T.

doi:10.1016/0920-1211(87)90029-5

Cited by 10 publications

(6 citation statements)

References 29 publications

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“…Besides, there are studies suggesting that seizure activity can be moderated via zinc administration [191][192][193]. However, some results are contradictory due to the type of epilepsy, the dose and the route of administration of zinc.…”

Section: Zinc Seizures and Epilepsymentioning

confidence: 99%

Insights into Potential Targets for Therapeutic Intervention in Epilepsy

Zavala-Tecuapetla

Cuéllar-Herrera

Luna-Munguía

2020

IJMS

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Epilepsy is a chronic brain disease that affects approximately 65 million people worldwide. However, despite the continuous development of antiepileptic drugs, over 30% patients with epilepsy progress to drug-resistant epilepsy. For this reason, it is a high priority objective in preclinical research to find novel therapeutic targets and to develop effective drugs that prevent or reverse the molecular mechanisms underlying epilepsy progression. Among these potential therapeutic targets, we highlight currently available information involving signaling pathways (Wnt/β-catenin, Mammalian Target of Rapamycin (mTOR) signaling and zinc signaling), enzymes (carbonic anhydrase), proteins (erythropoietin, copine 6 and complement system), channels (Transient Receptor Potential Vanilloid Type 1 (TRPV1) channel) and receptors (galanin and melatonin receptors). All of them have demonstrated a certain degree of efficacy not only in controlling seizures but also in displaying neuroprotective activity and in modifying the progression of epilepsy. Although some research with these specific targets has been done in relation with epilepsy, they have not been fully explored as potential therapeutic targets that could help address the unsolved issue of drug-resistant epilepsy and develop new antiseizure therapies for the treatment of epilepsy.

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Section: Zinc Seizures and Epilepsymentioning

confidence: 99%

Insights into Potential Targets for Therapeutic Intervention in Epilepsy

Zavala-Tecuapetla

Cuéllar-Herrera

Luna-Munguía

2020

IJMS

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“…Excessive release of Zn has been observed in an animal model of epilepsy [7]. Overall levels of Zn in the hippocampus appear to increase markedly as a result of kindling in rats [8].…”

Section: Introductionmentioning

confidence: 99%

Investigating the Role of Zinc in a Rat Model of Epilepsy

Baraka

Nabi

Ghotni

2011

CNS Neuroscience & Therapeutics

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“…In human temporal lobe epilepsy, as well as in several animal models of epilepsy, sprouting of mossy fibers (Cavazos et al., 1991) is observed by an increase in zinc‐sensitive Timm’s stain. Overall levels of zinc in the hippocampus appear to increase markedly as a result of kindling in rats (Mody & Miller, 1985; Slevin et al., 1986; Kasarskis et al., 1987).…”

Section: Introductionmentioning

confidence: 99%

Hippocampal zinc infusion delays the development of afterdischarges and seizures in a kindling model of epilepsy

et al. 2009

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SUMMARY Purpose Zinc occurs in high concentration in synaptic vesicles of glutamatergic terminals including hippocampal mossy fibers. This vesicular zinc can be synaptically released during neuronal activity, including seizures. Zinc inhibits certain subtypes of N-methyl-D-aspartate (NMDA) and γ-aminobutyric acid (GABA)A receptors. By blocking NMDA excitation or GABA inhibition, an excess of zinc may alter the excitability of hippocampal circuits, which contribute to the development of seizures. Methods Twenty-one adult Wistar rats were implanted under anesthesia with Alzet pumps releasing vehicle, 10 μM ZnCl2 or 1,000 μM ZnCl2, at a rate of 0.25 μl/h continuously into the hippocampal hilus for 4 weeks. Kindling was performed by daily awake commissural stimulation at 60 Hz and afterdischarges were recorded from a dentate gyrus electrode. Development of behavioral Racine seizure stages was recorded by a blinded investigator. Results The development of behavioral Racine seizure stages was delayed only in rats infused with 1,000 μM ZnCl2 (p < 0.02). With completion of kindling at stimulation number 20, all groups had reached the same maximum level of behavioral seizures. The expected increased progression of afterdischarge duration was inhibited by both 10 μM ZnCl2 and 1,000 μM ZnCl2 infusion compared to control animals (p < 0.01). At stimulation number 18, all groups had reached the same maximum duration of afterdischarges. Discussion We conclude that excess infused zinc delayed the development of behavioral seizures in a kindling model of epilepsy. These data support the hypothesis that zinc synaptically released during seizures may alter hippocampal excitability similar to zinc infused in our experiment.

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Amygdalar kindling is associated with elevated zinc concentration in the cortex and hippocampus of rats

Cited by 10 publications

References 29 publications

Insights into Potential Targets for Therapeutic Intervention in Epilepsy

Insights into Potential Targets for Therapeutic Intervention in Epilepsy

Investigating the Role of Zinc in a Rat Model of Epilepsy

Hippocampal zinc infusion delays the development of afterdischarges and seizures in a kindling model of epilepsy

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