Amygdalar neuronal plasticity and the interactions of alcohol, sex, and stress

Retson, Tara; Hoek, Jan B.; Sterling, Robert C.; Bockstaele, Elisabeth J. Van

doi:10.1007/s00429-014-0851-4

Cited by 29 publications

(26 citation statements)

References 104 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Then, experimental mice were gently dried using paper towels, returned to their home cages and perfused 2 h later (n=3). Forced swim test is a common stressor already reported to increase c-Fos in the amygdala of rats (Retson et al, 2014; Zhu et al, 2011). The present protocol is a variation of one presented elsewhere (Heinrichs and Koob, 2006).…”

Section: Methodsmentioning

confidence: 99%

Neuroanatomical and functional characterization of CRF neurons of the amygdala using a novel transgenic mouse model

et al. 2015

View full text Add to dashboard Cite

The corticotrophin releasing factor (CRF)-producing neurons of the amygdala have been implicated in behavioral and physiological responses associated with fear, anxiety, stress, food intake and reward. To overcome the difficulties in identifying CRF neurons within the amygdala, a novel transgenic mouse line, in which the humanized Renilla reniformis green fluorescent protein (hrGFP) is under the control of the CRF promoter (CRF-hrGFP mice), was developed. First, the CRF-hrGFP mouse model was validated and the localization of CRF neurons within the amygdala was systematically mapped. Amygdalar hrGFP-expressing neurons were located primarily in the interstitial nucleus of the posterior limb of the anterior commissure, but also present in the central amygdala. Secondly, the marker of neuronal activation c-Fos was used to explore the response of amygdalar CRF neurons in CRF-hrGFP mice under different experimental paradigms. C-Fos induction was observed in CRF neurons of CRF-hrGFP mice exposed to an acute social defeat stress event, a fasting/refeeding paradigm or LPS administration. In contrast, no c-Fos induction was detected in CRF neurons of CRF-hrGFP mice exposed to restraint stress, forced swimming test, 48 h fasting, acute high fat diet (HFD) consumption, intermittent HFD consumption, ad libitum HFD consumption, HFD withdrawal, conditioned HFD aversion, ghrelin administration or melanocortin 4 receptor agonist administration. Thus, this study fully characterizes the distribution of amygdala CRF neurons in mice and suggests that they are involved in some, but not all, stress or food intake-related behaviors recruiting the amygdala.

show abstract

Section: Methodsmentioning

confidence: 99%

Neuroanatomical and functional characterization of CRF neurons of the amygdala using a novel transgenic mouse model

et al. 2015

View full text Add to dashboard Cite

show abstract

“…For example, chronic alcohol exposure leads to a sensitization of the stress response to a forced swim stress [159, 160]. Furthermore, there is a correlation between animals that exhibit higher behavioral reactivity to stress and those that self-administer more alcohol [161].…”

Section: Preclinical Studies Of Drug Administration and Stress Responmentioning

confidence: 99%

“…Along with these baseline alterations in signaling seen following alcohol administration, there is also an effect of chronic alcohol on neuronal responses to stress. When exposed to a forced swim stress, animals with a history of chronic alcohol intake exhibit increased neuronal activation, as indicated by increased c-Fos immunoreactivity, within the central nucleus of the amygdala [159]. Double-labeling revealed that this increase in stress-induced activation following chronic alcohol is mediated by CRF-positive cells [159], suggesting that stress engages the CRF system more following chronic alcohol.…”

Section: Preclinical Studies Of Drug Administration and Stress Responmentioning

confidence: 99%

“…When exposed to a forced swim stress, animals with a history of chronic alcohol intake exhibit increased neuronal activation, as indicated by increased c-Fos immunoreactivity, within the central nucleus of the amygdala [159]. Double-labeling revealed that this increase in stress-induced activation following chronic alcohol is mediated by CRF-positive cells [159], suggesting that stress engages the CRF system more following chronic alcohol. This is consistent with data demonstrating an increase in CRFR1 mRNA following chronic alcohol use and may be due, in part, to a decrease in basal CRF release [158, 171].…”

Section: Preclinical Studies Of Drug Administration and Stress Responmentioning

confidence: 99%

See 1 more Smart Citation

Substance use modulates stress reactivity: Behavioral and physiological outcomes

Fosnocht

Briand

2016

Physiology & Behavior

View full text Add to dashboard Cite

Drug addiction is a major public health concern in the United States costing taxpayers billions in health care costs, lost productivity and law enforcement. However, the availability of effective treatment options remains limited. The development of novel therapeutics will not be possible without a better understanding of the addicted brain. Studies in both clinical and preclinical models indicate that chronic drug use leads to alterations in the body and brain’s response to stress. Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis may shed light on the ability of stress to increase vulnerability to relapse. Further, within both the HPA axis and limbic brain regions, corticotropin-releasing factor (CRF) is critically involved in the brain’s response to stress. Alterations in both central and peripheral CRF activity seen following chronic drug use provide a mechanism by which substance use can alter stress reactivity, thus mediating addictive phenotypes. While many reviews have focused on how stress alters drug-mediated changes in physiology and behavior, the goal of this review is to focus on how substance use alters responses to stress.

show abstract

“…O álcool, tanto em curto como em logo prazo, promove profunda alteração no eixo HHA. O uso agudo de álcool ativa o eixo HHA, resultando em níveis elevados de glicocorticoides e diminuindo a ansiedade, ao passo que a exposição prolongada ao álcool promove hipertrofia adrenal e embotamento da resposta ao estresse, tendo efeito ansiogênico 20,21 . Também tem sido demonstrado que a desregulação do eixo HHA permanece mesmo após longos períodos de abstinência, interferindo nos mecanismos de coping frente a novos estressores e facilitando a recaída 22 .…”

Section: (Figura 1)unclassified

Transtornos relacionados ao uso de álcool e as mulheres: impacto nos circuitos integrativos e de neurorregulação do estresse

Ribeiro

Rennó

Ribeiro

et al. 2017

Debates em Psiquiatria

View full text Add to dashboard Cite

ResumoDisfunções na resposta ao estresse podem exercer um importante papel em alguns transtornos mentais. Uma gama cada vez maior de estudos demonstra que existem diferenças entre os sexos na prevalência de transtornos relacionados ao estresse e que mulheres com transtornos por uso de álcool têm diferentes desfechos negativos no funcionamento cerebral e em mecanismos de neuroadaptação quando comparadas aos homens. O consumo de álcool tem sido associado a alterações sutis e em longo prazo no eixo hipotálamo-hipófise-adrenal, que afetam a resposta adaptativa nos circuitos de neurorregulação do estresse. Pesquisas futuras nesse campo podem impactar positivamente o desenvolvimento de estratégias terapêuticas que levem em consideração abordagens gênero-específicas.Palavras-chave: Álcool, mulheres, resposta ao estresse, diferenças entre os sexos. AbstractDysfunctional stress response can play a key role in some mental disorders. An increasing number of studies have demonstrated sex differences in the prevalence of stress-related disorders. In particular, women with alcohol use disorders (AUDs) present different negative outcomes whe compared to men in terms of brain function e neuroadaptative mechanisms. Alcohol consumption has been associated with subtle, long-term hypothalamic-hypophysis-adrenal (HPA) axis alterations, affecting the adaptive response of stress neuroregulatory circuits. Future research in this field may positively influence the development of treatment strategies that take gender-specific approaches into consideration.Keywords: Alcohol, women, stress response, sex differences.Disfunções na resposta ao estresse podem exercer um importante papel em alguns transtornos mentais 1 . Embora no Brasil e no mundo homens bebam mais que as mulheres, até há pouco mais de uma década, praticamente não havia dados acerca do consumo de álcool entre as mulheres, exceto os provenientes de estudos epidemiológicos 2-4 . Programas de apoio e assistência a usuários de álcool pouco levam em consideração particularidades relativas ao gênero. Muitas mulheres abandonam o tratamento, mesmo em centros especializados, por não se sentir à vontade em um ambiente predominantemente masculino e praticamente com inexistência de programas que deem suporte a mulheres com problemas transtornos relacionados ao uso de álcool 5,6 . Atualmente, as mulheres bebem em quantidade e frequência muito parecidas às da população masculina, principalmente em amostras de mulheres mais jovens 7,8 . A literatura sugere diferenças bastante distintas entre os sexos. Alguns transtornos mentais são mais prevalentes no sexo feminino, entre eles os transtornos depressivos, transtorno de ansiedade generalizada e transtorno de estresse pós-traumático 9 . Em todos esses transtornos, o estresse exerce um papel importante na neurobiologia,

show abstract

Amygdalar neuronal plasticity and the interactions of alcohol, sex, and stress

Cited by 29 publications

References 104 publications

Neuroanatomical and functional characterization of CRF neurons of the amygdala using a novel transgenic mouse model

Neuroanatomical and functional characterization of CRF neurons of the amygdala using a novel transgenic mouse model

Substance use modulates stress reactivity: Behavioral and physiological outcomes

Transtornos relacionados ao uso de álcool e as mulheres: impacto nos circuitos integrativos e de neurorregulação do estresse

Contact Info

Product

Resources

About