Amygdalectomy in the free-ranging vervet (Cercopithecus Aethiops)

Kling, Arthur; Lancaster, Jane B.; Benitone, Jerry

doi:10.1016/0022-3956(70)90006-3

Cited by 73 publications

(33 citation statements)

References 3 publications

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“…This is based, in part, on autopsy, animal lesion studies, and functional imaging studies that have implicated the amygdala in autism and social behavior. In 1970, Kling and colleagues (Kling et al, 1970) studied vervets with amygdala lesions in the wild. The lesioned vervets were unresponsive to their group, failed to display appropriate social signals, withdrew from social interaction and were frequently killed by other members of the group.…”

Section: Introductionmentioning

confidence: 99%

Individuals with Autism Spectrum Disorder Show Normal Responses to a Fear Potential Startle Paradigm

Bernier

Dawson

Panagiotides

2005

J Autism Dev Disord

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The present study utilized a fear potentiated startle paradigm to examine amygdala function in individuals with autism spectrum disorder. Two competing hypotheses regarding amygdala dysfunction in autism have been proposed: (1) The amygdala is under-responsive, in which case it would be predicted that, in a fear potentiated startle experiment, individuals with autism would exhibit decreased fear conditioning and/or potentiation, and (2) The amygdala is over responsive, in which case an exaggerated potentiation of the startle response would be predicted. Fourteen adolescents and adults diagnosed with autism spectrum disorder and 14 age, gender, IQ, and anxiety level-matched typical adolescents and adults participated. Both participants with autism and typical participants potentiated the startle response following fear conditioning and no group differences in the latency or amplitude of the potentiated startle response were found. These results suggest that this aspect of amygdala function, namely fear conditioning and potentiation of the startle response, is intact in individuals with autism.

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Section: Introductionmentioning

confidence: 99%

Individuals with Autism Spectrum Disorder Show Normal Responses to a Fear Potential Startle Paradigm

Bernier

Dawson

Panagiotides

2005

J Autism Dev Disord

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“…In the wild, these inappropriate interactions with other monkeys led to repeated attacks, social isolation and eventual death. 58,59 Subsequent studies have shown that all of the emotional components of the Kluver-Bucy syndrome can be reproduced by removal of the amygdala and surrounding perirhinal and entorhinal cortex. [60][61][62][63][64][65] The tameness and excessive orality can be reproduced by lesions restricted to only the amygdala.…”

Section: Effects Of Lesions Of the Amygdala On Conditioned Fearmentioning

confidence: 99%

The amygdala: vigilance and emotion

2000

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Here we provide a review of the animal and human literature concerning the role of the amygdala in fear conditioning, considering its potential influence over autonomic and hormonal changes, motor behavior and attentional processes. A stimulus that predicts an aversive outcome will change neural transmission in the amygdala to produce the somatic, autonomic and endocrine signs of fear, as well as increased attention to that stimulus. It is now clear that the amygdala is also involved in learning about positively valenced stimuli as well as spatial and motor learning and this review strives to integrate this additional information. A review of available studies examining the human amygdala covers both lesion and electrical stimulation studies as well as the most recent functional neuroimaging studies. Where appropriate, we attempt to integrate basic information on normal amygdala function with our current understanding of psychiatric disorders, including pathological anxiety. Molecular Psychiatry (2001) 6, 13-34.

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“…One of us [Kling et al, 1970] studied the behavior of C. aethiops liv ing in natural social groups along the Zambezi River in central Africa. The behavior of several groups was studied intensively prior to experi mentation.…”

Section: Anatomical Considerationsmentioning

confidence: 99%

A Neural Substrate for Affiliative Behavior in Nonhuman Primates

Kling

Steklis²

1976

Brain Behav Evol

200

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Studies of social behavior following localized brain lesions in several species of Old World monkeys suggest there is an anatomical substrate for the maintenance of social bonds. Destruction of either the amygdaloid nuclei, orbital frontal cortex or temporal pole results in varying degrees of social isolation or marked reductions in affiliative behaviors depending upon the environmental and social setting. The relationship between the loss of affiliative behaviors subsequent to these lesions and other functions previously demonstrated to be represented in these neural structures is discussed.

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Amygdalectomy in the free-ranging vervet (Cercopithecus Aethiops)

Cited by 73 publications

References 3 publications

Individuals with Autism Spectrum Disorder Show Normal Responses to a Fear Potential Startle Paradigm

Individuals with Autism Spectrum Disorder Show Normal Responses to a Fear Potential Startle Paradigm

The amygdala: vigilance and emotion

A Neural Substrate for Affiliative Behavior in Nonhuman Primates

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