Amygdalin suppresses lipopolysaccharide-induced expressions of cyclooxygenase-2 and inducible nitric oxide synthase in mouse BV2 microglial cells

Abstract

These results show that amygdalin exerts anti-inflammatory and analgesic effects and it dose so probably by suppressing the mRNA expressions of COX-2 and iNOS.

Proteomic identification of calcium-binding chaperone calreticulin as a potential mediator for the neuroprotective and neuritogenic activities of fruit-derived glycoside amygdalin

“…Fruit-derived amygdalin is a naturally occurring glycoside with broad biological activities such as anticancer, antiatherosclerosis, anti-inflammation and immunomodulation [15][16][17][18]. Little is known about its effect on neuronal survival and differentiation.…”

“…1A) is one of the main active components in S. persicae as well as the seeds of other Rosaceae family members [14]. Amygdalin exerts a range of pharmacological activities for the treatment of cancer, asthma, hypertension, migraine, atherosclerosis and chronic inflammation [15][16][17][18]. Importantly, it was recently reported that amygdalin could reduce ischemic brain injury via regulating cerebrocellular energy metabolism [19].…”

Protective effect of amygdalin on epithelial–mesenchymal transformation in experimental chronic obstructive pulmonary disease mice

“…Amygdalin, a cyano-containing glycoside compound widely found in the seed of Rosaceae (Todorova, Pesheva, Iliev, Bardarov, & Todorova, 2017), is an active ingredient in bitter almonds. Its pharmacological effects are extensive, mainly including relief of cough and phlegm, and immunosuppressive (Hwang, Lee, Kim, Shim, & Hahm, 2008), immunomodulation, anti-inflammatory (Yang et al, 2007), antitumour (Makarevic et al, 2014), and anti-atherosclerosis activities (Jiagang et al, 2011). Amygdalin is a very popular anticancer adjuvant in Europe and America (Milazzo, Lejeune, & Ernst, 2007).…”

Bioactivity-Guided Fractionation Identifies Amygdalin as a Potent Neurotrophic Agent from Herbal MedicineSemen PersicaeExtract

“…Amygdalin is also present in several other related species such as apples, apricots, almonds, cherries, plums, and peaches [28–30]. Previous studies have demonstrated that amygdalin exhibited a wide range of biological activities including anti-inflammatory, anticancer, antihypertension, and antiatherosclerosis activities [27, 31–33]. However, the neurotrophic effect of amygdalin has not been fully investigated.…”