2013
DOI: 10.1016/j.neubiorev.2012.11.019
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Amygdalostriatal projections in the neurocircuitry for motivation: a neuroanatomical thread through the career of Ann Kelley

Abstract: In MacLean’s triune brain, the amygdala putatively subserves motivated behavior by modulating the “reptilian” basal ganglia. Accordingly, Ann Kelley, with Domesick and Nauta, influentially showed that amygdalostriatal projections are much more extensive than were appreciated. Caudal of the anterior commissure, the entire striatum receives afferents from deep basal nuclei of the amygdala. They highlighted that amygdalar projections to the rostral ventromedial striatum converged with projections from the ventral… Show more

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Cited by 40 publications
(29 citation statements)
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References 240 publications
(350 reference statements)
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“…The striatum receives converging inputs from many sources, prominently from the cerebral cortex, but also from the thalamus, amygdala, and elsewhere [21-24]. The striatum also receives dopamine signals that guide reinforcement learning; the learned associations between a particular state and the set of actions with the highest expected values establish a decision policy that then guides the subject’s behavior [25-29].…”
Section: Framework For Thinking About Attentionmentioning
confidence: 99%
“…The striatum receives converging inputs from many sources, prominently from the cerebral cortex, but also from the thalamus, amygdala, and elsewhere [21-24]. The striatum also receives dopamine signals that guide reinforcement learning; the learned associations between a particular state and the set of actions with the highest expected values establish a decision policy that then guides the subject’s behavior [25-29].…”
Section: Framework For Thinking About Attentionmentioning
confidence: 99%
“…Indeed, the NAc Shell receives relevant functional inputs from the BLA ( [134], for a recent review) and manipulation of local GABAergic circuits or of glutamatergic (GLU) inputs in the caudal portion of the NAc Shell elicits defensive responses in the rat, including anti-predator treading and bites aimed at the experimenter [135]. On the other hand, there is convincing evidence that stressful experiences powerfully modulate dopamine (DA) tonic levels in the NAc Shell and that increased DA tone in this brain area mediates expression of active coping responses, whereas low DA tone is associated with behavioral indices of helplessness [6,136], in processes also involving DA receptors and glutamate transmission [137,138].…”
Section: Serotonin and A Stress Coping Brain Networkmentioning
confidence: 99%
“…Likewise, the Bmotivation^construct was a critical element of learning theory during that era (Kimble 1950). Motivational factors, as they should, remain key to understanding human behavior today, but with a much greater focus on the neurobiology of motivation than in the past (Arnsten and Rubia 2012;Robinson et al 2014;Zorrilla and Koob 2013).…”
Section: Recommendations From the Iommentioning
confidence: 99%