Amylase and Lipase Enzymes as Factors Affecting Acute Organophosphorous Poisoning Morbidity and Mortality

Abstract

The organophosphorous insecticides (OPIs) is widely used. The toxicity of OPIs is related to many biochemical disorders, for example changes in serum amylase and lipase enzymes. Average duration of admission affects prognosis of poisoning severity and outcome. The aim of this work was to evaluate the role of average days of admission, serum amylase and lipase enzymes in assessing OPIs poisoning severity, outcome, and complications in acutely OPIs poisoned patients admitted to Poison control center at Zagazig University Hospitals. This study was carried out on 36 OPIs poisoned patients on 7 months duration from May 2019 till November 2019. We scored the cases on first day of admission using POP score. Serum amylase and lipase were calculated on the day of admission and repeated after 24h. Results: Cases ranged between 3 and 66 years old with a mean age of 32.7±17.96. Serum amylase was correlated with OPIs poisoning severity, outcome, and complications, but not predictor of them. Serum lipase was not correlated with OPIs poisoning severity, outcome, and complications. Average days of admission were correlated with OPIs poisoning severity, outcome, and complications but predictor of outcome only. It is recommended to do further studies with large sample size for more accurate evaluation of the correlation with organophosphorous insecticides poisoning.

Role of Paraoxonase-1 Enzyme in Prediction of Severity and Outcome of Acute Organophosphorus Poisoning: A Prospective Study

“…This was in agreement with Samy et al (2018), Eisa et al (2021) and who reported that the POP scale's severity and days of admission had a statistically significant relationship. Twayana et al (2019) noticed that the correlations of POP scale with lag time and atropinization dose, showed no statistical significance.…”

“…Samy et al (2018) reported that there were no statistical significance differences with respect to age and gender distribution between severe and moderate poisoning. On the contrary, Eisa et al (2021) reported that there was statistically significant relation between age of the studied patients and route of exposure with severity according to POP scale.…”

“…Chaudhary et al (2019) reported that out of 100 OPC patients, 57 (57%) were classified as mild, 38 (38%) moderate and five (5%) as severe poisoning. On the other hand, Eisa et al (2021) stated that 61.1% of studied patients had moderate toxicity, 25% had mild toxicity, while 13.9% had severe toxicity according to POP score. Also, Elagamy et al (2019) concluded that most patients presented with mild status but persons who tend to harm themselves usually ingest large amounts of rapidly acting highly toxic compounds and so more poisoning severity.…”