Amylin and the Integrated Control of Nutrient Influx

Young, Andrew

doi:10.1016/s1054-3589(05)52004-0

Cited by 30 publications

(18 citation statements)

References 58 publications

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“…First meal size was also reduced with the 0.056 g/kg sCT dose, but this dose did not affect total daily intake. This pattern of results is consistent with prior reports that amylin and sCT suppress feeding by reducing meal sizes, not meal frequencies in rodents (14,24,33,42). We did observe a reduction in both meal size and frequency with the highest dose tested, 1 g/kg.…”

Section: Discussionsupporting

confidence: 93%

Salmon calcitonin reduces food intake through changes in meal sizes in male rhesus monkeys

Bello

Kemm

Moran³

2008

American Journal of Physiology-Regulatory, Integrative and Comp

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Section: Discussionsupporting

confidence: 93%

Salmon calcitonin reduces food intake through changes in meal sizes in male rhesus monkeys

Bello

Kemm

Moran³

2008

American Journal of Physiology-Regulatory, Integrative and Comp

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“…In the periphery it has been observed that amylin reduces gastric acid secretion, slows gastric emptying, and reduces pancreatic glucagon secretion (15). Pancreatic β-cells are the major source of circulating amylin and it is generally believed that the role of amylin in appetite regulation is as a result of secretion from β-cells (16).…”

Section: Amylinmentioning

confidence: 99%

Effects of sugar solutions on hypothalamic appetite regulation

Colley¹,

Castonguay²

2015

Physiology & Behavior

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There are multiple hypotheses for the causes of the obesity epidemic. One such hypothesis is that dietary intake patterns have significantly shifted to include unprecedented amounts of refined sugar. We set out to determine some the unique metabolic changes that occur with initial exposure to dilute glucose, sucrose, high fructose corn syrup, or fructose solutions. Rats were given access to food, water and a sugar solution for 24 h, after which blood and tissues were collected. Fructose access (as opposed to other sugars investigated) resulted in a doubling of circulating triglycerides. Glucose consumption resulted in upregulation of 7 satiety related hypothalamic peptides whereas changes in gene expression were mixed for remaining sugars. Also, following multiple verification assays, 6 satiety related peptides were verified as being affected by sugar intake. These data provide evidence that not all sugars are equally effective in affecting the control of intake.

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“…Some but not all studies have shown that amylin may also increase the intermeal interval under certain conditions [4]. Besides inhibiting food intake, amylin also reduces the rate of gastric emptying and, therefore, delays the appearance of ingested nutrients in the circulation [8,9,10]. Furthermore, by inhibiting glucagon secretion [11], amylin suppresses the postprandial endogenous glucose production [12].…”

Section: Introductionmentioning

confidence: 99%

Diet-Derived Nutrients Modulate the Effects of Amylin on c-Fos Expression in the Area Postrema and on Food Intake

et al. 2007

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The pancreatic hormone amylin decreases food intake via activation of area postrema (AP) neurons. We investigated whether amylin’s potency to reduce food intake and to induce c-Fos expression in the AP/nucleus of the solitary tract region is affected by the feeding conditions and specifically by the macronutrient composition of the diet. Whereas a low dose of amylin (5 µg/kg s.c.) induced very little c-Fos expression in ad libitum chow fed rats, it caused a strong c-Fos expression in 24-hour food-deprived rats and in rats that received a nutrient-deficient non-caloric mash (NCM; vanilla-flavoured cellulose) 24 h before injection. To reveal the contribution of single nutrients to the low c-Fos expression after chow feeding, amylin-induced c-Fos was analyzed after feeding NCM that was selectively supplemented with glucose, fat (lard), or protein (casein), matching the intake of these nutrients of chow-fed rats. While the rats fed NCM supplemented with glucose or fat displayed an equally strong amylin-induced activation as fasted rats or rats fed plain NCM, a significantly lower c-Fos expression was observed in rats fed a protein-supplemented NCM or a NCM containing all three nutrients. In line with this lower activation, the same dose of amylin failed to reduce food intake in NCM/protein-fed rats, while amylin caused a reduction in feeding when animals received NCM, NCM/glucose, or NCM/fat. Interestingly, amylin effectively reduced food intake in ad libitum chow fed rats despite the low level of amylin-induced c-Fos expression in the AP under these conditions. We conclude that the anorectic potential of amylin may be attenuated by diet-derived proteins, whereas this effect appears to be overridden when the amount of carbohydrates/fat is high relative to the protein content, such as, e.g., in standard chow.

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Amylin and the Integrated Control of Nutrient Influx

Cited by 30 publications

References 58 publications

Salmon calcitonin reduces food intake through changes in meal sizes in male rhesus monkeys

Salmon calcitonin reduces food intake through changes in meal sizes in male rhesus monkeys

Effects of sugar solutions on hypothalamic appetite regulation

Diet-Derived Nutrients Modulate the Effects of Amylin on c-Fos Expression in the Area Postrema and on Food Intake

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