Amyloid Assembly Endows Gad m 1 with Biomineralization Properties

The struggle tells me I don’t belong, yet I will stand up and show up: A psychosociocultural exploration of how Latino/x male undergraduates’ name, process, and manifest their identities.

“…Students described the interview as an opportunity and responsibility as caballeros (Arciniega et al, 2008) to show up and serve Latinx communities as hombres de palabra (men of their word, Mirandé, 2016). This responsibility represented a higher order understanding of stepping into their Latino male cultural and strength-based values to honor their generational sacrifices, protect their families (Sáenz et al, 2018), and uphold Latinidad across campus communities (Castellanos et al, 2020). Increasingly so, they internalized educational responsibility and expectations (Castellanos et al, 2020) that must be understood through the intersection of social identities and the context of their cultural values.…”

“…This responsibility represented a higher order understanding of stepping into their Latino male cultural and strength-based values to honor their generational sacrifices, protect their families (Sáenz et al, 2018), and uphold Latinidad across campus communities (Castellanos et al, 2020). Increasingly so, they internalized educational responsibility and expectations (Castellanos et al, 2020) that must be understood through the intersection of social identities and the context of their cultural values. Thus, conveying curiosity and willingness to listen to students' testimonios (life-learned stories) to identify the strengthbased processes (Castellanos et al, 2020) inherent in their struggle and perseverance is recommended for all university personnel (e.g., counselors, advisors, instructors, and mentors).…”

“…Increasingly so, they internalized educational responsibility and expectations (Castellanos et al, 2020) that must be understood through the intersection of social identities and the context of their cultural values. Thus, conveying curiosity and willingness to listen to students' testimonios (life-learned stories) to identify the strengthbased processes (Castellanos et al, 2020) inherent in their struggle and perseverance is recommended for all university personnel (e.g., counselors, advisors, instructors, and mentors). For instance, posing the simple yet complexly nuanced question of "What does it mean for you to be a Latino male in higher education" is foundational to acknowledging, processing, and make-meaning of their educational experiences.…”

“…Students' educational struggles are exacerbated at different intersections (i.e., race, gender, and college generation) and academic contexts (e.g., intellectual, emotional, and geographical; Vasquez et al, 2020). Students seek their family values for guidance and support, in particular, their mothers (Ballysingh, 2021;Castellanos et al, 2020;Sáenz et al, 2020). As Latino/x males are often the first in their families to attend college (Excelencia in Education, 2019), relying on individual and group structures of support (e.g., student organizations) remains a critical process (Dueñas & Gloria, 2022).…”

Review: Response to crowded conditions reveals compact nucleus for amyloid formation of folded protein — R0/PR1

“…β-PV is an α-helical folded protein capable of binding Mg 2+ and/or Ca 2+ through two active EF-hand domains (Rall, 1996). Upon loss of the metal-ion ligands, which may occur due to low pH protonating the coordinating residues, or the chelating agent, ethylenediaminetetraacetic acid (EDTA), apo-β-PV readily forms amyloid fibrils (Martinez et al, 2015;Castellanos et al, 2018). We recently showed that apo-β-PV amyloid formation follows a nucleation-elongation mechanism where the nucleation step involves folded dimers connected by intermolecular disulfide bonds (Werner et al, 2020).…”