2024
DOI: 10.21203/rs.3.rs-4094121/v1
|View full text |Cite
Preprint
|
Sign up to set email alerts
|

Amyloid Beta – induced leptomeningeal cell JAK/STAT signalling regulates inflammatory responses of astrocytes in Alzheimer’s Disease

Mannthalah Abubaker,
Janelle Stanton,
Olwyn Mahon
et al.

Abstract: The pathological signature of Alzheimer's disease (AD) includes the accumulation of toxic protein aggregates, mainly consisting of amyloid beta (Aβ). Recent strides in fundamental research underscore the pivotal role of waste clearance mechanisms in the brain suggesting it may be an early indication of early-onset AD. This study delves into the involvement of leptomeningeal cells (LMCs), crucial components forming integral barriers within the clearance system, in the context of AD. In this study, we examined t… Show more

Help me understand this report
View published versions

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

0
0
0

Publication Types

Select...

Relationship

0
0

Authors

Journals

citations
Cited by 0 publications
references
References 75 publications
0
0
0
Order By: Relevance

No citations

Set email alert for when this publication receives citations?