Amyloid deposition in extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue: A clinicopathologic study of 5 cases

Zhang, Qi; Pocrnich, Cady E.; Kurian, Annie; Hahn, Angelika F.; Howlett, Christopher J.; Shepherd, Jessica; Rizkalla, Kamilia

doi:10.1016/j.prp.2015.08.007

Cited by 13 publications

(22 citation statements)

References 19 publications

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“…It is thought that immunoglobulin light chains, produced by neoplastic plasmacytoid cells, are not sufficient to deposit amyloid in low‐grade MALT lymphoma patients . Cases of MALT lymphoma with amyloid deposition have been reported in organs such as the orbit, lung, soft tissue and breast . However, there has been no report of MALT lymphoma with amyloid deposition in the thymus.…”

Section: Discussionmentioning

confidence: 99%

“…[12][13][14] Amyloid deposition in MALT lymphoma is rare, 3,5 and most reported cases of MALT lymphoma with amyloid deposits showed indolent clinical courses. 3 Amyloid deposition in MALT lymphoma is associated with peritumoral amyloid deposits, single organ involvement, and low or undetectable levels of circulating IgM monoclonal protein. 15 It is thought that immunoglobulin light chains, produced by neoplastic plasmacytoid cells, are not sufficient to deposit amyloid in low-grade MALT lymphoma patients.…”

Section: Discussionmentioning

confidence: 99%

“…Clinically, thymic MALT lymphoma is associated with autoimmune diseases and chronic inflammation, in particular Sjögren's syndrome . Amyloid deposition in MALT lymphoma is unusual and few cases have been reported . However, there have been no reports on amyloid deposition in thymic MALT lymphoma.…”

Section: Introductionmentioning

confidence: 99%

“…2 Amyloid deposition in MALT lymphoma is unusual and few cases have been reported. [3][4][5][6] However, there have been no reports on amyloid deposition in thymic MALT lymphoma. This report describes a case of thymic MALT lymphoma with amyloid deposition in a patient with myasthenia gravis.…”

Section: Introductionmentioning

confidence: 99%

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Amyloid deposition in thymic extranodal marginal zone lymphoma of mucosa‐associated lymphoid tissue in a patient with myasthenia gravis: A case report

et al. 2020

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Extranodal marginal zone lymphoma of mucosa‐associated lymphoid tissue (MALT) in the thymus is a rare disease. Furthermore, amyloid deposition in thymic MALT lymphoma has not been previously described. Here, we report a case of a 35‐year‐old man with thymic MALT lymphoma with amyloid deposition and myasthenia gravis. Chest computed tomography revealed an anterior mediastinal mass with internal cystic component and extensive calcification. Total thymectomy was performed and histopathologic findings were compatible with a diffuse amyloid deposition in extranodal marginal zone MALT lymphoma. The results indicate that thymic MALT lymphoma should be considered as a possible diagnosis in patients with a solid and cystic thymic mass and autoimmune disease, including myasthenia gravis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Amyloid deposition in thymic extranodal marginal zone lymphoma of mucosa‐associated lymphoid tissue in a patient with myasthenia gravis: A case report

et al. 2020

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“…The association of amyloid deposits with MZLs is rare [1], although it tends to be more common in cases of primary pulmonary MALT lymphomas [2]. To the best of our knowledge, two case reports of MZL with amyloid deposits associated with calcification and ossification were reported in the English literature.…”

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confidence: 93%