Amyloid-directed assembly of nanostructures and functional devices for bionanoelectronics

Wang, Xinyu; Li, Yingfeng; Zhong, Chao

doi:10.1039/c5tb00374a

Cited by 30 publications

(18 citation statements)

References 54 publications

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“…Recently, the amyloid fibrils are recognized as emergent and promising building blocks for natural and artificial functional materials, and natural systems widely adopt such structure in bioadhesion and biofilm formation of barnacles and microbial by constructing multiscale polyvalent molecular and structural interactions with underlying substrate . In contrast to mussel‐inspired polydopamine film, the amyloid‐derived system could potentially afford transparent and colorless proteinaceous coating that is more desirable for advanced materials.…”

Section: Introductionmentioning

confidence: 99%

Phase‐Transited Lysozyme as a Universal Route to Bioactive Hydroxyapatite Crystalline Film

Yang

Tao

et al. 2017

Adv Funct Materials

121

109

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A key factor for successful design of bioactive complex, organic-inorganic hybrid biomaterials is the facilitation and control of adhesion at interfaces, as many current synthetic biomaterials are inert, lacking interfacial bio activity. In this regard, the development of a simple, unified way to bio functionalize diverse organic and inorganic materials toward biomineralization remains a critical challenge. In this report, a universal biomimetic mineralization route that can be applied to virtually any type and morphology of scaffold materials is provided to induce nucleation and growth of hydroxyapatite (HAp) crystals based on phase-transited lysozyme (PTL) coating. Surface-anchored abundant functional groups in the PTL enrich the interface with strongly bonded calcium ions, facilitating the formation of HAp crystals in simulated body fluid with the morphology and alignment being similar to that observed in natural HAp in mineralized tissues. By the adhesion of amyloid contained in the PTL, such protein assembly could readily integrate HAp on ceramics, metals, semiconductors, and synthetic polymers irrespective of their size and morphology, with robust bonding stability and corresponding ultralow wear extent under normal bone pressure. This strategy successfully improves the in vivo osteoconductivity of Ti-based implant, underpinning the expectation for such biomaterial in future biointerface and tissue engineering.

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Section: Introductionmentioning

confidence: 99%

Phase‐Transited Lysozyme as a Universal Route to Bioactive Hydroxyapatite Crystalline Film

Yang

Tao

et al. 2017

Adv Funct Materials

121

109

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“…Peptide‐ and protein‐based hybrid nanomaterials are therefore increasingly finding applications in different fields such as biomedicine, electronics, biosensing, and imaging. [1b,5,6]…”

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confidence: 99%

Hybrid Nanoscopy of Hybrid Nanomaterials

Bondia

Jurado

Casado

et al. 2017

Small

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The combination of complementary techniques to characterize materials at the nanoscale is crucial to gain a more complete picture of their structure, a key step to design and fabricate new materials with improved properties and diverse functions. Here it is shown that correlative atomic force microscopy (AFM) and localization-based super-resolution microscopy is a useful tool that provides insight into the structure and emissive properties of fluorescent β-lactoglobulin (βLG) amyloid-like fibrils. These hybrid materials are made by functionalization of βLG with organic fluorophores and quantum dots, the latter being relevant for the production of 1D inorganic nanostructures templated by self-assembling peptides. Simultaneous functionalization of βLG fibers by QD655 and QD525 allows for correlative AFM and two-color super-resolution fluorescence imaging of these hybrid materials. These experiments allow the combination of information about the topography and number of filaments that compose a fibril, as well as the emissive properties and nanoscale spatial distribution of the attached fluorophores. This study represents an important step forward in the characterization of multifunctionalized hybrid materials, a key challenge in nanoscience.

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“…[15] Since then, as a result of using self-assembled amyloid aggregates as templates or building blocks, a great deal of organic-inorganic hybrid materials for biomedical applications have been created. [16][17][18][19] For instance, self-assembly fibrinogen nanofibrils can take place of collagen as a template to regulate hydroxyapatite (HAp) mineralization for bone tissue regeneration. [20] In the terms of compositions, structures, and features, amyloid aggregates take many advantages for fabricating the organic-inorganic hybrid materials: i) they can be formed by many kinds of peptides and proteins providing rich raw materials; [21] ii) the preparation can be facilely controlled in vitro to obtain diverse structures and mechanical properties for constructing multifunctional hybrid materials; iii) abundant functional groups on the surface as binding sites can mediate the growth and organization of inorganic components, and the amino acid sequence of peptide precursors can be designed according to the desirable properties; [12] iv) the robust adhesion to both hydrophilic and hydrophobic surfaces determines the structural homogeneity of final nanocomposites; [22] v) they exhibit high mechanical strength and strong resistance to a wide variety of harsh physical conditions and hydrolase, [21,23] which enable their usage in synthesizing inorganic nanoparticles by chemical reduction and extend the service life of implanted hybrid biomaterials in body.…”

Section: Introductionmentioning

confidence: 99%

Amyloid‐Mediated Fabrication of Organic–Inorganic Hybrid Materials and Their Biomedical Applications

Zhao

Yang

2020

Adv Materials Inter

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nanostructures can be organized into a hierarchical architecture, thus giving their excellent physical and chemical properties. [1,6,7] Accordingly, protein-based biomimetic mineralization has been became an inspiration for synthesis of the highperformance organic-inorganic hybrid materials. Recently, many reviews have been published to report the progress of biomimetic organic-inorganic nanocomposites. Wang et al. reviewed the preparation of layered organic-inorganic nanocomposites inspired by nacre and indicated the advantages and disadvantages of various biomimetic strategies. [8] Zhang et al. summarized recent research on graphene-based artificial nacre nanocomposites and focused on the interface interactions design. [9] Wang et al. discussed functional protein-based organic-inorganic hybrid nanomaterials with an emphasis on the novel preparation methods, resulting nanostructures, and their potential applications in drug delivery and enzymatic catalysis. [10] Yao et al. summarized the fabrication of artificial layered structural nanocomposites based on the different inorganic building blocks, such as clays, ceramic nanoparticles, layered double hydroxides, calcium carbonate, and graphene. [11] Zhao et al. overviewed the synthesis and performance enhancement strategies for different dimensional nacre-inspired materials such as 1D fibers, 2D films, and 3D bulk composites. [6] The reviews mentioned above are mainly focused on the strategies to construct layered organic-inorganic hybrid materials and their applications in various fields, and the interface design to obtain high-performance structural nanocomposites. Although it has been demonstrated that the protein components function as templates involving in the biomineralization, the regulation on their structure and the mediation of proteins on the fabrication of hybrid materials are seldom presented, mainly because of their complex molecular structure and uncontrollable selfassembly process in vitro. Amyloid is a kind of insoluble self-assembly peptide or protein aggregate displaying polymorphic mesoscopic structures. [12] Even though the amyloids are originally discovered as the pathological hallmarks of human neurodegenerative diseases, it is found that there are also many nonpathogenic functional amyloid aggregates implicated in biological processes occurring in a variety of organisms ranging from simple bacteria to humans, such as the adhesive property of E. coil biofilms, [13] biosynthesis Protein assembly with ordered architecture plays an important role in the formation of natural organic-inorganic hybrid materials, and also determines their distinguished mechanical, optical, and biochemical properties. Nevertheless, it has been a huge challenge to synthesize materials with hierarchical structure accurately mimicking the natural hybrid materials in vitro. In the past decade, protein amyloid aggregates, due to their diverse and controllable nanostructures and unique properties, have been developed as superior templates or building blocks to fabricate f...

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Amyloid-directed assembly of nanostructures and functional devices for bionanoelectronics

Cited by 30 publications

References 54 publications

Phase‐Transited Lysozyme as a Universal Route to Bioactive Hydroxyapatite Crystalline Film

Phase‐Transited Lysozyme as a Universal Route to Bioactive Hydroxyapatite Crystalline Film

Hybrid Nanoscopy of Hybrid Nanomaterials

Amyloid‐Mediated Fabrication of Organic–Inorganic Hybrid Materials and Their Biomedical Applications

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