Amyloid Heart Disease

Nemshah, Yaser; Clavijo, Alex; Sharma, Gyanendra

doi:10.15420/usc.2018.5.1

Cited by 2 publications

(1 citation statement)

References 48 publications

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“…Furthermore, the special decreased longitudinal strain pattern with apical sparing on the speckle tracking echocardiography image, as a hallmark of cardiac amyloidosis, may raise the suspicion of the disease. Thickening of the valves, interatrial septum and ventricular wall with myocardial granular sparkling and minimal pericardial effusion are further echocardiographic characteristics associated with cardiac amyloidosis [ 107 , 109 ]. Castaño and coworkers found that patients with concurrent aortic valve stenosis and transthyretin amyloidosis had a 56% one-year all-cause mortality compared with 20% of patients with isolated aortic stenosis [ 110 ].…”

Section: The Imaging Of Aortic Valve Degeneration In Clinical Practicementioning

confidence: 99%

Cellular Senescence, Aging and Non-Aging Processes in Calcified Aortic Valve Stenosis: From Bench-Side to Bedside

Molnár

Pásztor

Merkely

2022

Cells

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Aortic valve stenosis (AS) is the most common valvular heart disease. The incidence of AS increases with age, however, a significant proportion of elderly people have no significant AS, indicating that both aging and nonaging pathways are involved in the pathomechanism of AS. Age-related and stress-induced cellular senescence accompanied by further active processes represent the key elements of AS pathomechanism. The early stage of aortic valve degeneration involves dysfunction and disruption of the valvular endothelium due to cellular senescence and mechanical stress on blood flow. These cells are replaced by circulating progenitor cells, but in an age-dependent decelerating manner. When endothelial denudation is no longer replaced by progenitor cells, the path opens for focal lipid deposition, initiating subsequent oxidation, inflammation and micromineralisation. Later stages of AS feature a complex active process with extracellular matrix remodeling, fibrosis and calcification. Echocardiography is the gold standard method for diagnosing aortic valve disease, although computed tomography and cardiac magnetic resonance are useful additional imaging methods. To date, no medical treatment has been proven to halt the progression of AS. Elucidation of differences and similarities between vascular and valvular calcification pathomechanisms may help to find effective medical therapy and reduce the increasing health burden of the disease.

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Section: The Imaging Of Aortic Valve Degeneration In Clinical Practicementioning

confidence: 99%

Cellular Senescence, Aging and Non-Aging Processes in Calcified Aortic Valve Stenosis: From Bench-Side to Bedside

Molnár

Pásztor

Merkely

2022

Cells

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Transthyretin Cardiac Amyloidosis and Aortic Stenosis: Connection and Therapeutic Implications

Peñalver

Ambrosino

Jeon

et al. 2020

CCR

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Background: There is growing interest in the observed significant incidence of transthyretin cardiac amyloidosis in elderly patients with aortic stenosis. Approximately 16% of patients with severe aortic stenosis undergoing aortic valve replacement have transthyretin cardiac amyloidosis. Outcomes after aortic valve replacement appear worse in patients with concomitant transthyretin cardiac amyloidosis. Method: Publications in PubMed, Cochrane Library, and Embase databases were systematically searched from January 2012 to September 2018 using the keywords transthyretin, amyloidosis, and aortic stenosis. All studies published in English that reported the prevalence, association and outcomes of transthyretin cardiac amyloidosis in patients with aortic stenosis undergoing were included. Results/Conclusion: The relationship between aortic stenosis and transthyretin cardiac amyloidosis is not well understood. A few studies have proven successful surgical management when both conditions coexist. This systematic review suggests that transthyretin cardiac amyloidosis is common in elderly patients with aortic stenosis and tend to have high mortality rates after AVR. The significant incidence of the two diseases occurring simultaneously warrants further investigation to improve management strategies in the future.

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Amyloid Heart Disease

Cited by 2 publications

References 48 publications

Cellular Senescence, Aging and Non-Aging Processes in Calcified Aortic Valve Stenosis: From Bench-Side to Bedside

Cellular Senescence, Aging and Non-Aging Processes in Calcified Aortic Valve Stenosis: From Bench-Side to Bedside

Transthyretin Cardiac Amyloidosis and Aortic Stenosis: Connection and Therapeutic Implications

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