Amyloid myopathy presenting with rhabdomyolysis: Evidence of complement activation

Rodolico, Carmelo; Mazzeo, Anna; Toscano, Antonio; Pastura, C.; Maimone, Davide; Musumeci, O.; Musolino, Caterina; Vita, Giuseppe

doi:10.1016/j.nmd.2006.06.004

Cited by 14 publications

(3 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Both ultrastructural and TUNEL studies have shown that muscle injury is not due to amyloid induced apoptosis 11 . The role of the complement cascade, assessed via immunolabeling with C5b9 membrane attack complex, is uncertain, with some studies reporting no immunolabeling 11 and others showing complement deposition colocalizing with amyloid 13 . We believe that myocyte injury in amyloidosis may be multifactorial, including ischemia 11 (supported by the focal reduction in the number of capillaries seen in our cases), interference with the diffusion of nutrients through the sarcolemma 11 , and/or denervation.…”

Section: Bmentioning

confidence: 99%

Myopathy as the Initial Manifestation of Primary Amyloidosis

Keith

Afshar-Ghotli²,

Roussev³

et al. 2011

Can. J. Neurol. Sci.

View full text Add to dashboard Cite

A 63 year-old man had a past medical history of diabetes and hypertension, did not smoke or drink alcohol, and had no relevant family history. Over the course of several months he developed left leg weakness and difficulty climbing stairs. He denied other symptoms including fever, sweats, chills, shortness of breath or chest pain. On general examination he had no adenopathy or hepatosplenomegaly. Neurological examination revealed focal weakness of the left hip flexor but was otherwise normal. Electromyography (EMG) showed a myopathic process. A biopsy was performed on an unspecified leg muscle.

show abstract

Section: Bmentioning

confidence: 99%

Myopathy as the Initial Manifestation of Primary Amyloidosis

Keith

Afshar-Ghotli²,

Roussev³

et al. 2011

Can. J. Neurol. Sci.

View full text Add to dashboard Cite

show abstract

“…Our patient had a normal CK level. In the literature, the CK level has been shown to range from normal to a 490‐fold increase with rhabdomyolysis 17, 23, 24. Although amyloidosis has been described in patients with non‐Hodgkin lymphoma,25 the amyloidosis in our patient was unlikely to be related to his history of NHL.…”

Section: Discussionmentioning

confidence: 55%

Primary amyloidosis presenting as “dropped head syndrome”

Chuquilin¹,

Al‐Lozi²

2011

Muscle and Nerve

View full text Add to dashboard Cite

show abstract

“…Furthermore, amyloid myopathy can be an initial manifestation of ATTRwt ( 6 ). And our patient presented with only the elevated CK as the initial manifestation of AL amyloidosis ( 16 ). Reviewing the clinical course of the patient, if a muscle biopsy and Congo red staining was performed at the beginning of CK elevation, the patient may be treated earlier.…”

Section: Discussionmentioning

confidence: 79%

Case Report: Systemic Amyloidosis Involving the Heart and Skeletal Muscle

et al. 2022

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

BackgroundAmyloidosis refers to an etiologically heterogeneous group of protein misfolding diseases characterized by extracellular deposition in organs and tissues of amyloid fibers, leading to severe organ dysfunction and death. Systemic amyloidosis often involves multiple organs. Heart and kidney are the most commonly affected organs, whereas skeletal muscle involvement is rare and often accompanied by other organs’ involvement.Case SummaryWe reported a 70-year-old man manifested with myopathy followed by heart failure who was suspected of transthyretin amyloidosis clinically, after the pathological results and the 99mTc-pyrophosphate (99mTc-PYP) scintigraphy, light-chain (AL) amyloidosis involving the heart and skeletal muscle was confirmed.ConclusionThe patient’s unique presentation gives insight into a rare but debilitating disorder and the potential link between various types of amyloidosis. In addition, myopathy in amyloidosis should be recognized.

show abstract

Amyloid myopathy presenting with rhabdomyolysis: Evidence of complement activation

Cited by 14 publications

References 11 publications

Myopathy as the Initial Manifestation of Primary Amyloidosis

Myopathy as the Initial Manifestation of Primary Amyloidosis

Primary amyloidosis presenting as “dropped head syndrome”

Case Report: Systemic Amyloidosis Involving the Heart and Skeletal Muscle

Contact Info

Product

Resources

About