Amyloid-β detection with saccharide immobilized gold nanoparticle on carbon electrode

Chikae, Miyuki; Fukuda, Tomohiro; Kerman, Kağan; Idegami, Koutarou; Miura, Yoshiko; Tamiya, Eiichi

doi:10.1016/j.bioelechem.2008.06.005

Cited by 128 publications

(63 citation statements)

References 32 publications

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“…[19][20][21] Tamiya's group firstly proposedt he electrochemical detection of Ab monomers (Ab and Ab ) by employing ad enselyp acked sialic acid-modified electrode which can specifically capture them. [19,22] The intrinsic oxidation signal of Ab at ap eak potential of 0.6 V( vs. Ag/AgCl) was monitored by differential pulse voltammetry.T he oxidation peak current of Ab showed as imilar tendencya sA b 1-40 ,a nd the peak current intensities were concentration-dependent from 0.5 mm to 10 mm.B ased on the intrinsic oxidation signal, am ultiplexed, implantable immunosensorw as also developed for quantification of the ratio of Ab 1-40 /Ab 1-42 using triple-barrel carbon fiber microelectrodes as the sensor platform. [23] Antibodies specific to Ab and Ab as the biorecognition element of the biosensor could selectively capture the Ab isoforms on the electrode surface.…”

Section: Electrochemical Sensorsmentioning

confidence: 99%

Detection of Aβ Monomers and Oligomers: Early Diagnosis of Alzheimer's Disease

Zhou

Liu

Hao

et al. 2016

Chemistry An Asian Journal

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Alzheimer's disease (AD), as the most common progressive neurodegenerative disorder, is pathologically characterized by deposition of extracellular plaque composed of amyloid-β peptide (Aβ). Different assembled states of Aβ have been considered as both important biomarkers and drug targets for the diagnosis and therapy of AD. Recent studies demonstrate that small, diffusible Aβ oligomers formed by aggregation of Aβ monomers are the major toxic agents in AD. Therefore, the development of reliable assays for Aβ (both monomers and oligomers) will be important for the early differential diagnosis of dementia, predicting the progression of AD, as well as monitoring the effectiveness of novel anti-Aβ drugs for AD. In this review, we summarize the recent progress made in the development of techniques for detection of Aβ monomers and oligomers. In particular, the principles governing the design of these sensors are classified and summarized. Moreover, the advantages and disadvantages of the assays are evaluated. This review also discusses the improvements and challenges for application of these assays in the early diagnosis of AD.

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Section: Electrochemical Sensorsmentioning

confidence: 99%

Detection of Aβ Monomers and Oligomers: Early Diagnosis of Alzheimer's Disease

Zhou

Liu

Hao

et al. 2016

Chemistry An Asian Journal

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“…More emphasis was taken to monitor the first four hours of aggregation, and these interactions were observed through the well-documented oxidation peak of the lone Tyr residue intrinsic to Ab peptides [44,[65][66][67][68][69] at approximately 0.7 V (vs. Ag/AgCl). Electrochemical measurements done in this study were supplemented with simultaneous fluorescence measurements using the well-defined ThT as the indicator of b-sheet formation during aggregation [70][71][72].…”

Section: Ab42 and Ab16 Aggregation In The Absence Of Metal Ionsmentioning

confidence: 99%

Label-free electrochemical detection of Amyloid beta aggregation in the presence of iron, copper and zinc

Hung

Masoom

Kerman

2012

Journal of Electroanalytical Chemistry

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“…Detection of the Tyr based electrooxidation signal was successfully used to monitor the in vitro aggregation of synthetic peptides representing Ab isoforms Ab and Ab(1-42) [18], as well as to study the impact of sym-triazine derivatives and the b-sheet breaker pentapeptide on Ab(1-42) aggregation kinetics [19,20]. The intrinsic oxidation signal of synthetic peptides Ab and Ab(1-42) due to the presence of the single Tyr residue was also used for the electrochemical sensing of the Ab-saccharide interaction and was suggested for the development of Ab sensor [21].…”

Section: Introductionmentioning

confidence: 99%