Amyloid β oligomer induces cerebral vasculopathy via pericyte-mediated endothelial dysfunction
Siqi Chen,
Daji Guo,
Yuanyuan Zhu
et al.
Abstract:Background
Although abnormal accumulation of amyloid beta (Aβ) protein is thought to be the main cause of Alzheimer’s disease (AD), emerging evidence suggests a pivotal vascular contribution to AD. Aberrant amyloid β induces neurovascular dysfunction, leading to changes in the morphology and function of the microvasculature. However, little is known about the underlying mechanisms between Aβ deposition and vascular injuries. Recent studies have revealed that pericytes play a substantial role in… Show more
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