Amyloidosis and Cardiac Surgery

Žáček, Pavel; Harrer, Jan

doi:10.5772/19524

Cited by 2 publications

(8 citation statements)

References 48 publications

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“…Prominent valvular amyloid deposits causing severe valve regurgitation are uncommon. A few report have described heart valvular surgery in patients diagnosed with cardiac amyloidosis [ 3 ]. To the best of our knowledge, no previous cases have been reported in which the initial manifestation of cardiac amyloidosis was severe tricuspid regurgitation, which was treated with tricuspid valve replacement.…”

Section: Discussionmentioning

confidence: 99%

“…Approximately half of patients with AL amyloidosis expire due to cardiac involvement. However, cardiac amyloidosis patients who already have suffered heart failure have very poor prognoses [ 4 ] because the only therapeutic surgical option is heart transplantation [ 3 ]. Therefore, the early detection of cardiac amyloidosis and proper treatment of the underlying cause of amyloidosis are critical to ensure an optimal outcome.…”

Section: Discussionmentioning

confidence: 99%

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Isolated Tricuspid Regurgitation: Initial Manifestation of Cardiac Amyloidosis

Yoon

Park

Kim

et al. 2015

Korean J Thorac Cardiovasc Surg

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Amyloid deposits in the heart are not exceptional in systemic amyloidosis. The clinical manifestations of cardiac amyloidosis may include restrictive cardiomyopathy, characterized by progressive diastolic and eventually systolic bi-ventricular dysfunction; arrhythmia; and conduction defects. To the best of our knowledge, no previous cases of isolated tricuspid regurgitation as the initial manifestation of cardiac amyloidosis have been reported. We describe a rare case of cardiac amyloidosis that initially presented with severe tricuspid regurgitation in a 42-year-old woman who was successfully treated with tricuspid valve replacement. Unusual surgical findings prompted additional evaluation that established a diagnosis of plasma cell myeloma.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Isolated Tricuspid Regurgitation: Initial Manifestation of Cardiac Amyloidosis

Yoon

Park

Kim

et al. 2015

Korean J Thorac Cardiovasc Surg

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“…At the first glance, diagnosing CA seems relatively straight forward. However, some of the difficulties in reaching a timely diagnosis include the rarity of the disease, late presentation of diverse clinical symptoms, and the existence of various subtypes 14 . CA is also often mistaken for hypertrophic cardiomyopathy with left ventricular outflow tract obstruction 7 .…”

Section: Camentioning

confidence: 99%

“…CA is also often mistaken for hypertrophic cardiomyopathy with left ventricular outflow tract obstruction 7 . Thus, a surprise encounter on the operating table is not uncommon, but significant advancements in diagnostic methods should decrease such scenarios moving forward 14 …”

Section: Camentioning

confidence: 99%

“…An ECHO is very useful in illustrating the morphological changes that occur over time in an amyloidotic heart and has 87% sensitivity for CA 14 ; however, the reliability may vary with the practitioner's familiarity with CA on ECHO. There is an increase in biventricular and biatrial wall thickness, with no change in chamber size and dilatation, respectively 14 . The atria undergo dilatation to withstand filling pressures 14 .…”

Section: Camentioning

confidence: 99%

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Amyloidosis and cardiovascular diseases: A clinical insight

et al. 2020

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Systemic amyloidosis is caused by the deposition of amyloid proteins in varying organ systems throughout the body, leading to dysfunction within those systems. The development of cardiac amyloidosis is one of the main indicators of poor prognosis in patients. Cardiac amyloidosis is most commonly caused by the immunoglobulin light chain amyloidosis and the transthyretin amyloidosis. Both have poor prognoses when associated with cardiac amyloidosis; however, the patients with the former subtype fair far worse than those with the latter. Despite amyloidosis having a history of being underdiagnosed, recent epidemiological data indicate that the rate of diagnosis has increased, which has coincided with improved in-patient median survival rates. It is of great importance that patients are diagnosed with the correct subtype as the main treatment strategy is to treat the underlying cause of amyloidosis. If a misdiagnosis is made, patients can receive treatment that might be ineffective or even harmful. A great progress has been made in pharmacological treatments for treating the underlying causes; however, many of the proposed treatments still need more evidence to support their use.

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Amyloidosis and Cardiac Surgery

Cited by 2 publications

References 48 publications

Isolated Tricuspid Regurgitation: Initial Manifestation of Cardiac Amyloidosis

Isolated Tricuspid Regurgitation: Initial Manifestation of Cardiac Amyloidosis

Amyloidosis and cardiovascular diseases: A clinical insight

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