Amyloidosis of the gastrointestinal tract: a 13-year, single-center, referral experience

Cowan, Andrew J.; Skinner, Martha; Seldin, David C.; Berk, John L.; Lichtenstein, David R.; O’Hara, Carl; Doros, Gheorghe; Sanchorawala, Vaishali

doi:10.3324/haematol.2012.068155

Cited by 166 publications

(195 citation statements)

References 25 publications

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“…Liver can be involved in several amyloidoses, including AL [45][46][47], AA [10], AApoAI [11], and ALys [48,49]. Increase in alkaline phosphatase and hepatomegaly document involvement of this organ, whereas transaminases are usually normal or slightly increased.…”

Section: Use Of Biomarkers For Early Diagnosismentioning

confidence: 99%

Biochemical markers in early diagnosis and management of systemic amyloidoses

Lavatelli

Albertini

Fonzo

et al. 2014

Clinical Chemistry and Laboratory Medicine (CCLM)

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Systemic amyloid diseases are characterized by widespread protein deposition as amyloid fibrils. Precise diagnostic framing is the prerequisite for a correct management of patients. This complex process is achieved through a series of steps, which include detection of the tissue amyloid deposits, identification of the amyloid type, demonstration of the amyloidogenic precursor, and evaluation of organ dysfunction/damage. Laboratory medicine plays a central role in the diagnosis and management of systemic amyloidoses, through the quantification of the amyloidogenic precursor and evaluation of end-organ damage using biomarkers.

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Section: Use Of Biomarkers For Early Diagnosismentioning

confidence: 99%

Biochemical markers in early diagnosis and management of systemic amyloidoses

Lavatelli

Albertini

Fonzo

et al. 2014

Clinical Chemistry and Laboratory Medicine (CCLM)

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“…In systemic amyloidosis, the heart, kidneys, and nerves are most commonly affected, resulting in congestive heart failure, arrhythmia, nephrotic syndrome, renal failure, and peripheral and autonomic neuropathies [4]. Isolated gastrointestinal amyloidosis is rare [5]. In one series, the most common presentations for gastrointestinal amyloidosis were weight loss (45%) and gastrointestinal bleeding (36%) [5].…”

Section: Discussionmentioning

confidence: 99%

“…Isolated gastrointestinal amyloidosis is rare [5]. In one series, the most common presentations for gastrointestinal amyloidosis were weight loss (45%) and gastrointestinal bleeding (36%) [5]. In another report, the most common symptoms of gastrointestinal amyloidosis were diarrhea (45.8%), anorexia (37.5%), weight loss and nausea and/or vomiting (29.2%) and the histologically confirmed gastrointestinal tract site was the stomach (55.0%), colon (45.0%) and rectum (35.0%).…”

Section: Discussionmentioning

confidence: 99%

Amyloidosis of the colon

Dawkins¹,

Hanchard²,

Lee³

2017

IJCRI

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International Journal of Case Reports and Images (IJCRI) is an international, peer reviewed, monthly, open access, online journal, publishing high-quality, articles in all areas of basic medical sciences and clinical specialties.Aim of IJCRI is to encourage the publication of new information by providing a platform for reporting of unique, unusual and rare cases which enhance understanding of disease process, its diagnosis, management and clinico-pathologic correlations.IJCRI publishes Review Articles, Case Series, Case Reports, Case in Images, Clinical Images and Letters to Editor. Website: www.ijcasereportsandimages.com Amyloidosis of the ColonYvonne M. Dawkins, Barrie Hanchard, Michael G. Lee ABSTRACT Introduction: Gastrointestinal amyloidosis is rare in western countries. The most frequent clinical manifestation in all patients with amyloidosis is weight loss and gastrointestinal bleeding. However, diarrhea is seen in patients with secondary amyloidosis. Case Report: A 76-year-old male presented with a six-month history of diarrhea, and had three episodes of bloody diarrhea over a two-day period prior to admission. There was associated anorexia and weight loss. Colonoscopy revealed pancolitis and a presumptive diagnosis of ulcerative colitis was made. He had resolution of his diarrhea after four days on prednisone. However, biopsy revealed colonic amyloid deposition. He also had non-nephrotic range proteinuria and cardiomyopathy and likely had systemic amyloidosis, affecting the heart and kidney in addition to colonic involvement. Conclusion:The intestinal presentation may be similar to several conditions as a result of the protean manifestations of gastrointestinal amyloidosis. A high index of suspicion should be maintained in any patient presenting with chronic diarrhea and edema to avoid delay in diagnosis and treatment.

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“…Amyloid deposition in the gastrointestinal (GI) tract can manifest as macroglossia, GI bleeding, abdominal pain, impaired intestinal transit (possibly enhanced by autonomic neuropathy), malabsorption, perforation, acute intestinal obstruction or hepatic injury [3]. GI bleeding was the second most frequent symptom of amyloidosis (36%), after weight loss (45%), and closely followed by heartburn (33%) [4]. Congo red stains of gastric biopsies are recommended for monoclonal gammopathy patients with unexplained weight loss, GI bleeding, abdominal pain, or early satiety [4].…”

Section: Discussionmentioning

confidence: 99%