Amyloïdosis, sarcoidosis and systemic lupus erythematosus

Abstract

The occurrence of renal and multiple organ Amyloïdosis is currently considered exceptional in the course of systemic lupus erythematosus. We report a case of a concomitant SLE and Amyloïdosis in a 57 year old female patient with hypothyroidism history, who presented with erythema nodosum, fever, arthralgia and sicca syndrome. Biological findings showed an inflammatory syndrome, renal failure, proteinuria (1g / 24h), positive auto antibodies and anti DNA. Lung radiology revealed medistinal lymphadenopathy, pleural nodules, ground glass infiltrates and pleuritis. Bronchial biopsy showed non specific inflammation. The salivary gland biopsy showed amyloïd deposits. This case report reminds us that lupus and Amyloïdosis association, although exceptional remains possible. The occurrence of Lofgren syndrome in this situation make the originality of this report.

Kidney amyloidosis in patients with systemic lupus erythematosus

“…Of note, the period of time between the diagnoses of SLE and amyloidosis may vary from 1 year to 35 years. 2 We suggest that amyloidosis, although uncommon, should be considered in the differential diagnosis of proteinuria in patients with SLE.…”

Sarcoidosis: Various Presentations, Coexisting Diseases and Malignancies

“…The sex-stratified analyses demonstrated a remarkable association of ankylosing spondylitis and sarcoidosis in both sexes, however, Sjogren's syndrome is seen more in females and autoimmune thyroid disease is seen more in male patients respectively [10]. Sarcoidosis occurring concurrently with diseases like systemic lupus erythematosus and amyloidosis is also reported in the literature [29]. Some of the articles that we used for this review showing the association between sarcoidosis and other diseases are summarized in Table 1.…”

Erythema nodosum in rheumatic diseases

“…Авторы полагают, что УЭ в 3% случаев может быть первым проявлением СКВ. Другие авторы представили случай СКВ с амилоидозом у 57-летней женщины, у которой наблюдалась УЭ и рентгенологические изменения, соответствующие 2-й стадии саркоидоза [20].…”