Amyopathic Dermatomyositis Associated With Familial Polyposis Coli

Abstract

We report on a 13-year-old girl with an 8-year history of severe psoriasis with inflammatory, discoid plaques involving the trunk and limbs treated with a humanized antitumor necrosis factor (anti-TNF)-α monoclonal antibody (infliximab). The patient was particularly bothered by severe, fissured, confluent, hyperkeratotic plaques on the palms and soles (Fig. 1A) that limited day-to-day activities and sports such as tennis. Intensive topical therapy and courses of phototherapy were ineffective. A minimal response was obtained with methotrexate and only partial improvement occurred with cyclosporine administered over a 1-year period. Subsequent courses of mycophenolate mofetil and acitretin also failed to induce further improvement. Figure 1. Emília, a cloth doll with molluscum contagiosum.