Amyotrophic Lateral Sclerosis: Impact of Pulmonary Follow-Up and Mechanical Ventilation on Survival. A Study of 114 Cases

Sanjuán-López, Pilar; Valiño-López, Paz; Ricoy-Gabaldón, Jorge; Verea-Hernando, Héctor

doi:10.1016/j.arbr.2014.10.008

Cited by 17 publications

(19 citation statements)

References 17 publications

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“…The oculomotor limitation in ALS patients with TIV is initially with a supranuclear mechanism (30-32), but in the advanced stage of TLS the brainstem oculomotor nucleus is also involved neuropathologically (9,33), and is the focus survival, the disease progression never stops and often shows a wide and multisystem distribution of neurodegenerative lesions spreading to areas other than the motor system (9). Our patients with TIV showed much longer survival lengths than previously reported (Table II) (23)(24)(25)(26)(27)(28), and we needed predictors not only for survival but also to aid in the maintenance of care interventions. Seriously disabled patients with TIV cannot be evaluated even with the extended version of ALSFRS-R (29).…”

Section: Discussionmentioning

confidence: 68%

Predictors of impaired communication in amyotrophic lateral sclerosis patients with tracheostomy-invasive ventilation

Nakayama

Shimizu

Mochizuki

et al. 2015

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

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Predictors of communication impairment in patients with amyotrophic lateral sclerosis (ALS) using tracheostomy-invasive ventilation (TIV) were investigated. Seventy-six ALS patients using TIV were enrolled and classified into three subgroups of communication ability: patients who could communicate with communication devices (Stage I), patients who had difficulty with communication (Stage II, III, or IV), and patients who could not communicate by any means (Stage V). Predictors of communication impairment were analysed by the Cox proportional hazard model. Results demonstrated that there were no significant differences in disease duration between subgroups. Within 24 months after disease onset, patients who needed TIV and tube feeding, developed oculomotor impairment or became totally quadriplegic and progressed from Stage I to II and V significantly earlier. Multivariate analyses revealed that within 24 months from onset, the need for TIV and progression to total quadriplegia were significant events in patients who progressed to Stage II, whereas the development of oculomotor limitation was significant in patients who progressed to Stage V. In conclusion, TIV, impaired oculomotor movement and total quadriplegia are predictors of severe communication impairment. Rapid disease progression might indicate future communication impairment after the use of TIV. We highly recommend early detection of impaired communication and identification of the best methods of communication.

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Section: Discussionmentioning

confidence: 68%

Predictors of impaired communication in amyotrophic lateral sclerosis patients with tracheostomy-invasive ventilation

Nakayama

Shimizu

Mochizuki

et al. 2015

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

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“…Several studies have reported beneficial effects of NIV [2][3][4][5][6][7][8][9][10][11] or its ability to postpone respiratory function decline [3] and respiratory muscle strength decline [9] within 4 months of follow-up. NIV initiation in ALS patients is reported within a range 42% AE 13% to 65% AE 14% of FVC% predicted and 31%-36% of MIP% [7][8][9][10]19].…”

Section: Discussionmentioning

confidence: 99%

Impact of an early respiratory care programme with non‐invasive ventilation adaptation in patients with amyotrophic lateral sclerosis

Vitacca

Montini

Lunetta

et al. 2018

Euro J of Neurology

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“… 51 In contrast to previously published case series, Chadwick et al 53 showed that 14 out of 30 patients with motor neuron disease were successfully weaned from tracheostomy ventilation, although all had continuing requirements for NIV. 54 – 56 The overall survival after hospital discharge was 57%, with 1 year survival of 43.3%. Survival from the initiation of ventilatory support was similar for patients treated with emergency intubation and for those who started elective NIV.…”

Section: Interface For Continuous Nivmentioning

confidence: 99%

Continuous noninvasive ventilation for respiratory failure in patients with amyotrophic lateral sclerosis: current perspectives

Fiorentino

Annunziata

Gaeta

et al. 2018

DNND

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Respiratory failure is a recognized late complication of amyotrophic lateral sclerosis. It is related to the neurological progression of the diseases with the impairment of the respiratory musculature. Survival and quality of life of amyotrophic lateral sclerosis patients is improved by using noninvasive mechanical ventilation. The rate of long-term mechanical ventilation is different within and between countries. Cultural factors, socioeconomic conditions, and physician attitude often influence the decision to start noninvasive ventilation. Technical elements, like the choice of the correct interface, solid caregivers support, and the communication between the patient and the physician are essential for achieving therapeutic goals, especially in the case of continuous treatment.

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Amyotrophic Lateral Sclerosis: Impact of Pulmonary Follow-Up and Mechanical Ventilation on Survival. A Study of 114 Cases

Cited by 17 publications

References 17 publications

Predictors of impaired communication in amyotrophic lateral sclerosis patients with tracheostomy-invasive ventilation

Predictors of impaired communication in amyotrophic lateral sclerosis patients with tracheostomy-invasive ventilation

Impact of an early respiratory care programme with non‐invasive ventilation adaptation in patients with amyotrophic lateral sclerosis

Continuous noninvasive ventilation for respiratory failure in patients with amyotrophic lateral sclerosis: current perspectives

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