2024
DOI: 10.3390/cells13010099
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Amyotrophic Lateral Sclerosis Mechanism: Insights from the Caenorhabditis elegans Models

Lili Chen,
Shumei Zhang,
Sai Liu
et al.

Abstract: Amyotrophic Lateral Sclerosis (ALS) is a debilitating neurodegenerative condition characterized by the progressive degeneration of motor neurons. Despite extensive research in various model animals, the cellular signal mechanisms of ALS remain elusive, impeding the development of efficacious treatments. Among these models, a well-characterized and diminutive organism, Caenorhabditis elegans (C. elegans), has emerged as a potent tool for investigating the molecular and cellular dimensions of ALS pathogenesis. T… Show more

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