An 8-Week Randomized, Double-Blind Trial Comparing Efficacy, Safety, and Tolerability of 3 Vilazodone Dose-Initiation Strategies Following Switch From SSRIs and SNRIs in Major Depressive Disorder

Rele, Shilpa; Millet, Robert; Kim, Sungman; Paik, Jong Hoo; Kim, Seonghwan; Masand, Prakash S.; Patkar, Ashwin A.

doi:10.4088/pcc.14m01734

Cited by 7 publications

(2 citation statements)

References 9 publications

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“…The efficacy of vilazodone for patients with MDD who failed to respond to a prior trial of antidepressant has received only limited investigation. In an 8-week randomized trial of 70 adults with MDD who had an inadequate response to previous treatment with SSRIs or SNRIs, 45 subjects received vilazodone at starting doses of 10, 20, or 40 mg/day. There was a significant reduction in MADRS total score from baseline to week 8 in the sample as a whole; however, there were no significant differences in antidepressant efficacy between any of the vilazodone treatment groups.…”

Section: Clinical Efficacymentioning

confidence: 99%

Vilazodone for Major Depression in Adults: Pharmacological Profile and an Updated Review for Clinical Practice

Chauhan¹,

Parry²,

Bobo³

2022

NDT

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This article provides an updated review of the pharmacological profile and available efficacy and tolerability/safety data for vilazodone, one of the most recent antidepressant drugs to be approved in the USA for the treatment of major depressive disorder (MDD) in adults. The efficacy of vilazodone for MDD in adults is supported by four positive short-term (8–10 weeks), randomized, placebo-controlled trials. Beyond these pivotal trials, we review updated research findings pertaining to the clinical effects of vilazodone for MDD including the results of switch studies, small comparative efficacy trials, key pooled and secondary data analyses focused on important depressive subtypes (anxious depression) and predictors of treatment outcome, and safety studies including direct studies of sexual side-effects. Despite these additional research efforts and use for over a decade, important gaps in the clinical evidence base remain with vilazodone. Hypothesized differences in efficacy and adverse effects between other antidepressants and vilazodone based on its multimodal mechanism of action (combining serotonin reuptake inhibition with serotonin 5-HT1A partial agonist effects) have not been comprehensively demonstrated in clinical studies and its effectiveness as a continuation- or maintenance-phase therapeutic is not yet established. Questions remain regarding its reproductive and lactational safety profiles and its efficacy as a potential next-step therapeutic for patients with MDD who do not respond to first-line antidepressants such as selective serotonin reuptake inhibitors. Suggestions for clinical use of vilazodone and discussion of its place among the broad range of pharmacotherapies for adults with MDD are provided.

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Section: Clinical Efficacymentioning

confidence: 99%

Vilazodone for Major Depression in Adults: Pharmacological Profile and an Updated Review for Clinical Practice

Chauhan¹,

Parry²,

Bobo³

2022

NDT

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“…The discontinuation rates due to AEs were higher with vilazodone than placebo [41]. The most common AEs of vilazodone were vomiting, nausea, diarrhea, insomnia, somnolence, dizziness, and dry mouth [35].…”

Section: Reviewmentioning

confidence: 99%

A Review of Novel Antidepressants: A Guide for Clinicians

Faquih¹,

Memon²,

Hafeez³

et al. 2019

Cureus

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This review article aims to provide insight into the mechanisms of action, pharmacokinetics, clinical efficacy, safety and tolerability of four novel antidepressants including desvenlafaxine, vortioxetine, vilazodone, and levomilnacipran. Following keywords are used in PubMed and Scopus to search for relevant articles: (depression) AND (psychopharmacology OR desvenlafaxine OR levomilnacipran OR vortioxetine OR vilazodone). Patients with a lack of effectiveness or tolerability to certain antidepressants may get benefit from selecting a new antidepressant with different mechanism of action. These medications can be an option in the selection of newer antidepressants. Depression may not be caused by the simple deficiency of serotonin in the brain, but rather a complex interplay of various neurotransmitters including serotonin, norepinephrine, glutamate, and histamine at certain brain areas. The above-mentioned novel antidepressants exert their therapeutic benefits by acting on multiple neurotransmitters. The complexity of underlying the neurobiological mechanism should be considered while formulating a plan of care.

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