An 8-year-old boy with severe disseminated<i>Staphylococcus aureus</i>infection

Wangjirapan, Anchalee; Kongthavonsakul, Kritsana; Oberdorfer, Peninnah

doi:10.1136/bcr-2012-007398

Cited by 3 publications

(3 citation statements)

References 18 publications

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“…Since 2010, we have identified 15 reported cases of paediatric PVL-SA severe infections and Table 1 summarizes the main results of these reports regarding the clinical presentations, radiological findings, treatment and outcome [2][3][4][5][15][16][17][18][19][20][21][22][23].…”

Section: Discussionmentioning

confidence: 99%

“…Here we have described a case of a 6-month-old infant with a severe disseminated PVL-MRSA infection with the aim of increasing attention and knowledge on this type of infection, in which a high suspicious is essential for a prompt diagnosis and to start adequate treatment [ 4 , 5 ].…”

Section: Discussionmentioning

confidence: 99%

“…Fever. Subsequent multilobar pneumonia and pericardial effusion, septicaemia Right proximal tibial osteomyelitis (MRI) Intravenous fluoxacillin, which was substituted on day 9 by intravenous linezolid and daptomycin on day 11 and oral clindamycin MSSA genotype not clarified Intravenous linezolid 21 days, intravenous daptomycin 19 days, clindamycin 30 days (which was continued at home) Arthroscopic washout Complete resolution Wangjirapan, 2012, Thailand [ 4 ] 1 8-years, M Fever, low back pain, dyspnoea, abdomen distension with guarding and moderate tenderness, endocarditis Paravertebral abscess, multiple consolidations in the bilateral basal lungs, pleural effusion, thrombosis inferior vena cava, left common iliac vein, proximal left internal iliac vein, small liver abscess, osteomyelitis 5th lumbar vertebral body (CT). Intravenous cloxacillin, clindamycin and gentamicin.…”

Section: Discussionmentioning

confidence: 99%

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Panton-valentine leukocidin Staphylococcus aureus severe infection in an infant: a case report and a review of the literature

et al. 2021

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Background Panton-Valentine leukocidin (PVL) is one of the major virulence factor of Staphylococcus aureus (SA) that might be associated with invasive life-threating infections. A prompt diagnosis and adequate treatment are essential in achieving the best outcome and avoiding serious sequelae. We describe a case of severe invasive PVL-SA infection in an infant. A literature review starting from 2010 was also performed in order to discuss clinical presentations, radiological findings, treatment and outcome. Case presentation This is a case of a 6-month-old boy who rapidly developed high fever and poor general condition. He was diagnosed as having multiple muscular abscesses, multiple foci of osteomyelitis and bloodstream infections caused by Panton-Valentine leukocidin Methicillin-resistant Staphylococcus aureus. He received intravenous antibiotics and surgical drainage of the abscess with progressive recovery. Conclusion Our report highlights the importance of improving awareness of this severe infection, as a prompt diagnosis and adequate manage is essential in order to save life and to prevent serious complications.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Panton-valentine leukocidin Staphylococcus aureus severe infection in an infant: a case report and a review of the literature

et al. 2021

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Persistent back pain in the absence of clear red flags

Ledford

Linthicum

2013

BMJ Case Reports

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Evaluation of Challenges in Diagnosis of Spontaneous Subacute Pyogenic Spondylodiscitis in Immunocompetent Patients: Experiences from a Tertiary Care Center

et al. 2019

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Study Design Prospective clinical study. Purpose We evaluated the challenges faced during diagnosis and management of patients with subacute pyogenic discitis and discussed various clues in clinical history, radiologic and hematologic parameters of these patients that helped in establishing their diagnosis. Overview of Literature Present literature available shows that in patients with subacute spondylodiscitis and infection with less virulent organisms, the clinical picture often is confusing and the initial radiologic and hematologic studies do not contribute much toward establishing the diagnosis. Methods Demographic pattern, predisposing factors, clinical presentation, comorbidities, microbiology, treatment, neurologic recovery, and complications of 11 patients were prospectively reviewed regarding their contribution toward the conformation of diagnosis of subacute pyogenic discitis. Results Mean age at presentation was 46.0 years with average preoperative Oswestry Disability Index and Visual Analog Scale scores of 83.4 and 7.18, respectively. Mean follow-up duration was 12.0 months. The most common site of infection was the lumbar spine, followed by the thoracic spine (n=1). Infective organisms were isolated in only 45% of cases. Staphylococcus aureus was the most common causative organism isolated. Conclusions Diagnosing subacute spondylodiscitis in a patient presenting with subacute low backache poses a diagnostic challenge. Clinical and radiologic picture are deceiving, and bacteriologic results often are negative, further complicating the picture. A detailed medical history along with clinical, radiologic, and biochemical parameters prevents missing the diagnosis. Serial serum Creactive protein and alkaline phosphatases were more reliable blood parameters in cases of subacute presentation.

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An 8-year-old boy with severe disseminatedStaphylococcus aureusinfection

Cited by 3 publications

References 18 publications

Panton-valentine leukocidin Staphylococcus aureus severe infection in an infant: a case report and a review of the literature

Panton-valentine leukocidin Staphylococcus aureus severe infection in an infant: a case report and a review of the literature

Persistent back pain in the absence of clear red flags

Evaluation of Challenges in Diagnosis of Spontaneous Subacute Pyogenic Spondylodiscitis in Immunocompetent Patients: Experiences from a Tertiary Care Center

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