An 8-year review of major congenital abnormalities in a tertiary hospital in Lagos, Nigeria

Fajolu, Iretiola; Ezenwa, Beatrice Nkolika; Akintan, Patricia; Ezeaka, Chinyere

doi:10.4314/njp.v43i3.4

Cited by 1 publication

(7 citation statements)

References 7 publications

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“…This implies that congenital malformation might not have a predilection for a particular gender. This finding is corroborated by previous studies 8 …”

Section: Discussionsupporting

confidence: 93%

“…3 The cardiovascular system was the commonest system affected in this study. This finding is similar to a study by Fajola et al 8 but at variance with other studies which have reported CNS, 6 digestive system 12-14 as the commonest system affected. The difference in the observation is possibly due to the difference in the underlying etiology of the congenital malformation as related to a predominance of downs syndrome and the timing of the insult in relation to embryogenesis.…”

Section: Discussionsupporting

confidence: 92%

“…This shows that clinical screening alone may not be sufficient in detecting some congenital malformation, and may thus underestimate the true burden in our environment. 8 The prevalence of 6.1% in this study is similar to the prevalence rate of 6.3% reported in southwest Nigeria, which was also a hospital based but retrospective research. 7 Over 80% of the mothers in this study were registered for antenatal clinic and were compliant with antenatal drugs which are prescribed in accordance with the antenatal guideline for favorable pregnancy outcomes which include daily 5 mg of folic acid, 200 mg of fesolate and antimalaria.…”

Section: Discussionsupporting

confidence: 87%

“…This finding is corroborated by previous studies. 8 Congenital malformation was more prevalent among the term neonates compared to preterm. The reasons for this, is not clear, however, it may be that the insult to the organ system was probably at a later time in the third trimester or did not threaten the survival of the fetus.…”

Section: Discussionmentioning

confidence: 95%

“…4 The prevalence of congenital malformation varies from one region to another, however global prevalence of CM is about 2%-3%. 5 The prevalence of CM in Nigeria is reported to be between 2.8% and 15.9%, [6][7][8] which is likely to be underreported as most Nigerian studies on birth defects are mostly retrospective with the limitations of incomplete records.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Congenital malformations: Prevalence and characteristics of newborns admitted into Federal Medical Center, Asaba

Chimah

Emeagui

Ajaegbu

et al. 2022

Health Science Reports

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Background: Congenital malformations account for a significant cause of perinatal mortality and morbidity. Understanding the burden and pattern of congenital malformation is key in monitoring the trend and improving the health care of neonates especially those in low-income countries.Objective: This was a prospective cross-sectional study to determine the prevalence and characteristics of congenital malformations among neonates admitted to the neonatal unit.Method: All newborns with congenital malformation admitted into the neonatal unit of Federal Medical Center, Asaba whose parents gave consent were recruited for the study for a 1-year period from January 2020 to December 2020. Appropriately indicated laboratory and radio-diagnostic investigations were done to confirm internal anomalies. Data were collected using a structured questionnaire and analyzed with a statistical package for social sciences version 26.0. Results:The total admission for the period was 752 with 46 of the neonates (6.1%) having congenital malformation. The predominant system affected was the cardiovascular system (57%), central nervous system (33%), and digestive system (30%). Atrioventricular septal defect (31%) and patent ductus arteriosus (31%) were the commonest types of cardiovascular malformation. A significant number of newborns with congenital anomalies died (43.5%). Conclusion:Congenital malformation was seen among one in 18 neonates affecting mostly the cardiovascular and central nervous system. A high index of suspicion, early complete physical examination, and radio-diagnostic investigations are relevant for the complete evaluation of CM in neonates. Advanced maternal age was associated with the presence of multiple organ anomalies.

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“…This implies that congenital malformation might not have a predilection for a particular gender. This finding is corroborated by previous studies 8 …”

Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%