In this work, the neural performance and fuzzy logic data sheets of the transistor are used to determine the feasible design target space in the optimization of a microwave amplifier. The compatible (Noise F, Input VSWR V i , Gain G T ) triplets and their (Z S , Z L ) terminations of a microwave transistor are exploited for an amplifier design with the minimum noise F min (f), required gain G Treq (f), and a low input VSWR V i over the available bandwidth. The multi-objective design procedure is obtained from Z S (f), Z L (f) terminations with the unit-elements and short-circuited stubs in the LþL configurations and memetic optimization algorithm is successfully implemented as an optimization tool. A typical design example is given with its challenging performance in the simple LþL configurations realizable by the microstrip line technology. V C 2010 Wiley Periodicals, Inc. Int J RF and Microwave CAE 20:546-556, 2010.