An Abnormal Leukocyte Response in Interstitial Cystitis

Bohne, A. Waite; Hodson, John; Rebuck, John W.; Reinhard, Rinze

doi:10.1016/s0022-5347(17)64806-7

Cited by 41 publications

(7 citation statements)

References 12 publications

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“…T h e exuberant polymorphonuclear reaction to the skin abrasions observed in rheumatoid patients with the Rebuck skin window technic has been noted also in patients with interstitial cystitis (20) and ulcerative colitis (21) . Wilkinson et al (4) did not find such a reaction in patients with rheumatoid arthritis.…”

Section: Response To Igg In Ramentioning

confidence: 97%

In vivo and in vitro responses to autologous IgG in patients with rheumatoid arthritis

Runge

Mills

1971

Arthritis & Rheumatism

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The presence of rheumatoid factor in patients with rheumatoid arthritis remains unexplained and may be etiologically important. An attempt has been made to determine whether patients with seropositive rheumatoid arthritis show basic immunologic responses to IgG. Various immunologic parameters of antigen recognition were measured in 9 patients and 3 controls. No immediate or delayed cutaneous hypersensitivity was noted to native or aggregated autologous IgG, nor could in vitro lymphocyte blast cell transformation be induced with these proteins. Rebuck skin windows showed no unusual responsiveness to native IgG. The negative results indicate that either IgG is not the immunogen responsible for rheumatoid factor or that patients with rheumatoid arthritis retain a state of partial tolerance. Evidence supporting the concept that rheumatoid factor may interfere with the phlogistic potential of aggregated γ‐globulin was also found.

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Section: Response To Igg In Ramentioning

confidence: 97%

In vivo and in vitro responses to autologous IgG in patients with rheumatoid arthritis

Runge

Mills

1971

Arthritis & Rheumatism

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“…Many attempts have been made to discover the aetiology of the disease and to define proper criteria in discriminating between patients with interstitial cystitis and those with other types of chronic cystitis. The increased number of mast cells in the bladder wall of patients with interstitial cystitis has been known for some time, but the validity of the observation has been difficult to evaluate because of the different criteria used for clinical diagnosis (Simmons and Bunce, 1958;Bohne et al, 1962;Silk, 1970;Collan er al., 1976;De Juana and Everett, 1977). It has recently been proposed that a quantitative mast cell count in the detrusor muscle might help to establish a pathoanatomical diagnosis (Larsen et af., 1982).…”

mentioning

confidence: 99%

Histamine Content and Mast Cell Count of Detrusor Muscle in Patients with Interstitial Cystitis and Other Types of Chronic Cystitis

Kastrup

Hald

Larsen

et al. 1983

British Journal of Urology

157

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The quantitative mast cell count in the detrusor muscle, the histamine content and the degree of collagen staining material in the bladder wall have been evaluated in order to elucidate their value in distinguishing between patients with interstitial cystitis and other types of chronic cystitis. The number of mast cells in the detrusor muscle was statistically significantly increased in patients with interstitial cystitis compared with the control group (P less than 0.0001). With a proposed level of greater than 20 mast cells/sq mm of muscle tissue the diagnostic specificity was 88% and the diagnostic sensitivity 95%. The histamine content in the bladder wall was significantly increased in patients with interstitial cystitis (P less than 0.05) but not useful as a diagnostic test. The amount of collagen staining material was significantly increased in the intra- and inter-fascicular muscle tissue of the bladder in patients with interstitial cystitis (P less than 0.0005, P less than 0.001) and might be used as a support for the histological diagnosis, even in patients with uncontracted bladders.

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“…A moderately increased plasma cell count and some eosinophils are generally demon strable in the manner characteristic of autoimmune diseases. The mast cell count is increased and this has been considered to suggest the role of hista mine in the pathogenesis (2,21,25,26,38,40). However, not all authors have observed an increase in the mast cell count (35).…”

Section: Tissue Typingmentioning

confidence: 99%

Interstitial Cystitis as an Autoimmune Disease

Kj¹

1980

Eur Urol

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An Abnormal Leukocyte Response in Interstitial Cystitis

Cited by 41 publications

References 12 publications

In vivo and in vitro responses to autologous IgG in patients with rheumatoid arthritis

In vivo and in vitro responses to autologous IgG in patients with rheumatoid arthritis

Histamine Content and Mast Cell Count of Detrusor Muscle in Patients with Interstitial Cystitis and Other Types of Chronic Cystitis

Interstitial Cystitis as an Autoimmune Disease

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