An Abnormal Phosphoglucomutase Component in Chronic Lymphatic Leukaemia

Grosse‐Wilde²,

et al. 1975

Hum Genet

Genetic linkage between the HL-A and Bf loci could be confirmed in 43 families with 168 offspring. In 4 families, 5 recombinants out of 82 informative meiotic divisions were observed (r = 6.1%). The localisation of the Bf marker system was studied in 3 families with crossovers between HL-A and MLC. From these data the following map order of human chromosome 6 can be proposed: HL-A (1st locus) -- HL-A (2nd locus)--MLC-Bf---PGM(3). The fact that important components of the classical and alternate pathway of complement activation are governed by genes closely linked with HL-A and MLC loci leads to the proposition to include the Bf system into the Major Histocompatibility Complex in man.

Linkage group HL-A-MLC-Bf (properdin factor B)

Grosse‐Wilde²,

et al. 1975

Hum Genet

Phosphoglucomutase 3: Formal and Population Genetics and Observations on Abnormal Phenotypes¹

Kalbheim

1975

Vox Sanguinis

514 healthy blood donors and 47 families with 122 offspring were studied for phosphoglucomutase 3 (PGM3) from leukocytes. There was a good agreement of allelic frequencies obtained compared to those reported previously in Caucasians. In addition, three individuals with abnormal phenotypes were observed: one was a patient with Hodgkin's disease, the other two were apparently healthy blood donors. In two cases, family members could be studied; none carried the abnormal type of the father. The possible background of these observations with respect to the attachment of the PGM3 locus to the immunogenetic linkage group--the major histocompatibility complex--on chromosome No. 6 in man is discussed.

PGM₃ LOCUS AND ITS GENETIC POLYMORPHISM IN LEUCOCYTES OF GOATS

Pretorius¹,

Schmid

Osterhoff

et al. 1976

Int J Immunogenetics

SUMMARY PGM3 activity was investigated in 150 ‘Boerbok’ goats and 132 Angora goats by means of horizontal starch gel electrophoresis. In ‘Boerbok’ goats no polymorphism was found. In Angora goats three different phenotypes have been recognized: F, S, and FS. The results suggest the occurrence of two common alleles: PGM3‐F and PGM3‐S at an autosomal locus with frequencies of 0.6176 and 0.3824, respectively.