1972
DOI: 10.1007/bf01212161
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An abnormality of adrenaline, phentolamine stimulated lipolysis in adipose tissue from obese, maturity-onset diabetics

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1973
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Cited by 8 publications
(4 citation statements)
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“…In agreement with Atkinson and Randle (15) preliminary experiments indicated that phentolamine methane sulphonate alone had no effect on glycerol release from fat cells in concentrations up to 130 pM and that a concentration of 13 pM was sufficient for maximum enhancement of adrenaline stimulated lipolysis. Table 1 shows the amount of glycerol released during 2 hours incubation, in response to various concentrations of adrenaline in ehe presence of 13 pM phentolamine.…”
Section: The Release Of Glycerol In Fat Cells In Vitrosupporting
confidence: 84%
“…In agreement with Atkinson and Randle (15) preliminary experiments indicated that phentolamine methane sulphonate alone had no effect on glycerol release from fat cells in concentrations up to 130 pM and that a concentration of 13 pM was sufficient for maximum enhancement of adrenaline stimulated lipolysis. Table 1 shows the amount of glycerol released during 2 hours incubation, in response to various concentrations of adrenaline in ehe presence of 13 pM phentolamine.…”
Section: The Release Of Glycerol In Fat Cells In Vitrosupporting
confidence: 84%
“…It is therefore unlikely that changes in catecholamine receptor sensitivity are responsible for the increased flux of plasma fatty acids that is frequently observed in adult diabetes. A number of reasons may account for the discrepancy between our results and those of Atkinson and Randle [5]. The severity of diabetes mellitus at time of study, [19].…”
Section: Discussioncontrasting
confidence: 61%
“…It has recently been suggested that in adult diabetes there is impaired sensitivity of the beta-receptor of adipocytes, as judged by a reduced output of glycerol from adipose tissue following incubation with adrenaline and phentolamine [5]. Such a defect would be expected to lead to a decreased release of fatty acid from the tissue.…”
mentioning
confidence: 99%
“…3). Earlier studies in man have also shown blunting of NA-stimulated lipolysis in adipose tissue of juvenile diabetics [20] and diminished lipolytic response to NA plus phentolamine in adipose tissue of obese maturityonset diabetics [6]. In the present study, the ability of NA to increase the production of cAMP was abolished in adipose tissue of untreated diabetics.…”
Section: Catecholamine-induced Lipolysissupporting
confidence: 70%