2024
DOI: 10.1101/2024.11.26.624535
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An abundance ofaliCandaliDgenes were identified in saliva using a novel multiplex qPCR to characterize group II non-encapsulated pneumococci with improved specificity

Claire S. Laxton,
Femke L. Toekiran,
Tzu-Yi Lin
et al.

Abstract: Background: Surveillance of pneumococcus is reporting increasing prevalence of non-encapsulated pneumococci (NESp). NESp are an important reservoir for genetic exchange among streptococci, including for antimicrobial resistance (AMR), and are increasingly implicated in disease. Disease-associated NESp commonly carry the virulence genes pspK, or aliC and aliD in their cps locus instead of capsule genes. While molecular methods targeting the cps region are widely used for serotyping encapsulated strains, there a… Show more

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