An accurate and ultrasensitive SERS sensor with Au–Se interface for bioimaging and in situ quantitation

Abstract

We propose a stable and ultrasensitive Au–Se SERS nanoprobes for bioimaging and in situ quantitation, which is aim at breaking through the limitations of Au–S SERS nanoprobes, such as interference of biothiols, and unsatisfactory SERS efficiency.

Recent progress of surface-enhanced Raman spectroscopy for subcellular compartment analysis

“…The binding ways to metal are not limited to thoil, amino, and carboxyl groups anymore. In a recent study, Li and Tang et al 144 developed the selenol-based reporter molecules, and found that the Au-Se interface is more stable than the biosensors constructed by the Au-S bond, displaying good resistance to abundant thiol under the biological condition and show better stability. The increasingly demanding molecular designs based on full consideration of all these issues is an irresistible trend, and many organic and pharmaceutical chemists might engage in developing high-quality and multifunctional Raman reporters.…”

Versatile Graphene‐Isolated AuAg‐Nanocrystal for Multiphase Analysis and Multimodal Cellular Raman Imaging†

“…[ 17‐19 ] Au nanocrystals (Au NCs) with strong surface plasmonic resonance (SPR) properties and superior chemical stability have been extensively used as SERS substrates. [ 20‐23 ] Actually, Ag NCs possess larger optical absorption cross section and lower price than Au NCs, [ 24‐25 ] which endows the Ag NCs with greater potential for SERS bioanalysis theoretically. Nevertheless, Ag NCs are easily oxidized in O 2 or H 2 S‐contained environments [ 26‐27 ] and possess potential biotoxicity, [ 28‐29 ] and unnecessary chemical reactions may occur under laser excitation due to the direct contact between probe molecules and Ag NCs, [ 24 ] which severely hinders the SERS biological applications.…”

Triggering gold nanoparticles formation on a quartz surface by nanosecond pulsed laser irradiation

“…7,8 Although several methods have been developed for the obtention of cost-effective SERS substrates, [9][10][11] the fabrication of MNPs-based SERS-substrates remains a subject of current interest. [12][13][14] Surface-supported MNPs can be prepared using top-down approaches such as lithography, optical, electron beam, so, nanoimprint and polymer lithography, among others; obtaining highly ordered nanoparticle arrays. 6,15,16 However, these techniques are not quite simple to be implemented and involve several steps.…”