The teaching mode based on Outcomes-Based Education (OBE) is one of the newest outcomes in international engineering teaching reforms, which achieves expected study outcomes with student-centered ability-oriented methods. Based on OBE mode, a course design with theory and practice combination in "Analog CMOS Integrated Circuit Design" is proposed and analyzed in this paper. Based on the completely understanding of circuit theory, different design requirements relevant to specific engineering applications are presented to students with different abilities, which can induce positive impacts on improving the design ability of analog CMOS integrated circuits.