2022
DOI: 10.1039/d2sc01952c
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An acetyltransferase controls the metabolic flux in rubromycin polyketide biosynthesis by direct modulation of redox tailoring enzymes

Abstract: The often complex control of bacterial natural product biosynthesis typically involves global and pathway-specific transcriptional regulators of gene expression, which often limits the yield of bioactive compounds under laboratory conditions....

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Cited by 2 publications
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“…Modification of a key redox tailoring enzyme by an N -acetyltransferase has been shown to control metabolic flux during the biosynthesis of rubromycin polyketides such as griseorhodin A 26 . 21 The acetyl-CoA-dependent acetyltransferase GrhJ activates a flavoprotein monooxygenase GrhO6 allowing fast formation and release of its 5,6-spiroketal product. The biosynthetic mechanism for production of an aromatic resorcylic ring by a type 1 PKS has been elucidated by in vitro enzymatic production of the polyketide antibiotic pyoluteorin 27 .…”
mentioning
confidence: 99%
“…Modification of a key redox tailoring enzyme by an N -acetyltransferase has been shown to control metabolic flux during the biosynthesis of rubromycin polyketides such as griseorhodin A 26 . 21 The acetyl-CoA-dependent acetyltransferase GrhJ activates a flavoprotein monooxygenase GrhO6 allowing fast formation and release of its 5,6-spiroketal product. The biosynthetic mechanism for production of an aromatic resorcylic ring by a type 1 PKS has been elucidated by in vitro enzymatic production of the polyketide antibiotic pyoluteorin 27 .…”
mentioning
confidence: 99%