An Acromegalic Patient with Pulsatile Secretion of Growth Hormone (GH) Coincident with the Slow-Wave Sleep.

Matsuno, Megumi; Sohmiya, Motoi; Yamamoto, Hiroyuki; Kato, Yuzuru

doi:10.1507/endocrj.45.687

Cited by 5 publications

(2 citation statements)

References 24 publications

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“…In addition, a recently identified GH-releasing peptide, called Ghrelin, is likely to play a role in the regulation of pituitary GH secretion (Kojima et al 1999). The amplitude and frequency of GH secretory pulses are regulated by a complex array of external and internal stimuli including age (Corpas et al 1993, Arvat et al 1997, gender (Van den Berg et al 1996), oestrous cycle phase (Faria et al 1992), genetic background (Mendlewicz et al 1999), nutritional status (Riedel et al 1995), sleep (Matsuno et al 1998), disease status (Frohman et al 1992) and body composition (Ahmad et al 1989). In addition, hormones such as glucocorticoids and thyroid hormones (Devesa et al 1992) influence the pulsatile secretion pattern of GH.…”

Section: Introductionmentioning

confidence: 99%

Primary hypothyroidism in dogs is associated with elevated GH release

Diaz-Espineira²,

Mol³

et al. 2001

Journal of Endocrinology

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The pulsatile secretion patterns of GH were investigated in seven beagle bitches by collecting blood samples every 10 min for 6 h during euthyroidism and 1·5 years after induction of primary hypothyroidism. Hypothyroidism was induced by surgical removal of the thyroid gland and subsequent destruction of any remnant thyroid tissue by oral administration of sodium [131 I]iodide. Some of the physical changes observed in the dogs with primary hypothyroidism mimicked those of acromegaly. During both euthyroidism and hypothyroidism GH was secreted in a pulsatile fashion. The mean ( ...) basal plasma GH concentration was significantly higher (P=0·003) in the hypothyroid state (4·1 1·6 µg/l) than in the euthyroid state (1·2 0·4 µg/l). Likewise, the mean area under the curve (AUC) for GH above the zero-level during hypothyroidism (27·0 10·0 µg/l 6 h) was significantly higher (P=0·004) than that during euthyroidism (11·7 2·0 µg/l 6 h). The mean AUC for GH above the baseline was significantly lower (P=0·008) during hypothyroidism (2·4 0·8 µg/l 6 h) than during euthyroidism (4·5 1·8 µg/l 6 h), whereas there was no significant difference in GH pulse frequency. The mean plasma IGF-I level was significantly higher (P<0·01) in the hypothyroid state (169 45 µg/l) than in the euthyroid (97 15 µg/l). The results of this study demonstrate that primary hypothyroidism in dogs is associated with elevated basal GH secretion and less GH secreted in pulses. This elevated GH secretion has endocrine significance as illustrated by elevated plasma IGF-I levels and some physical changes mimicking acromegaly. It is discussed that the increased GH release in hypothyroid dogs may be the result of the absence of a response element for thyroid hormone within the canine pituitary GH gene and alterations in supra-pituitary regulation.

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Section: Introductionmentioning

confidence: 99%

Primary hypothyroidism in dogs is associated with elevated GH release

Diaz-Espineira²,

Mol³

et al. 2001

Journal of Endocrinology

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“…In healthy men, peak pulsatile GH secretion has a tendency to be secreted in the evening, with the occurrence of maximal GH release generally during periods of slowwave sleep (Holl, et al 1991;Matsuno, et al 1998), and an average of 8 pulses in a 24 h period (Ionescu and Frohman 2006;Stolar and Baumann 1986). The pulsatile release of GH displays a distinctive combination of low amplitude high frequency volleys every 30 to 60 min, complemented with high amplitude GH secretory bursts approximately every 2 to 3 h (Farhy and Veldhuis 2003;Hartman et al 1991).…”

Section: Figure 12 Schematic Diagram Of a Classic Pulsatile Profile mentioning

confidence: 99%

The effect of adiposity, age and deletion of acyl-ghrelin on pulsatile growth hormone release in male mice

Xie¹

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Growth Hormone in the Brain: Characteristics of Specific Brain Targets for the Hormone and Their Functional Significance

Nyberg

2000

Frontiers in Neuroendocrinology

219

170

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An Acromegalic Patient with Pulsatile Secretion of Growth Hormone (GH) Coincident with the Slow-Wave Sleep.

Cited by 5 publications

References 24 publications

Primary hypothyroidism in dogs is associated with elevated GH release

Primary hypothyroidism in dogs is associated with elevated GH release

The effect of adiposity, age and deletion of acyl-ghrelin on pulsatile growth hormone release in male mice

Growth Hormone in the Brain: Characteristics of Specific Brain Targets for the Hormone and Their Functional Significance

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