The field of human factors studies the interaction between humans and technological systems in order to optimize human–system performance, research that has traditionally been focused on observation and experiment in laboratory and real-world settings. However, a multidisciplinary subfield of human factors called human performance modeling has recently emerged that involves the development and application of mathematical models, computer simulation techniques, and computational data analysis methods to the study of human performance. This chapter provides an introduction to the use of computational modeling, simulation, and analysis techniques in human factors research, with an eye toward how such methods may be used to optimize human performance in extreme settings.