2008
DOI: 10.1158/0008-5472.can-07-5111
|View full text |Cite
|
Sign up to set email alerts
|

An Actin-Binding Protein Girdin Regulates the Motility of Breast Cancer Cells

Abstract: Girdin (girders of actin filaments) is a novel actin-binding Akt substrate that plays an important role in actin organization and Akt-dependent cell motility in fibroblasts.

Help me understand this report
View preprint versions

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1

Citation Types

14
208
1

Year Published

2009
2009
2016
2016

Publication Types

Select...
9

Relationship

0
9

Authors

Journals

citations
Cited by 167 publications
(223 citation statements)
references
References 33 publications
14
208
1
Order By: Relevance
“…These findings raise the possibility that regulation of cell polarization by the PAR-3-AP-2α-Girdin pathway might be impaired in cells that lose expression of these proteins during prostate cancer progression. Girdin has been reported to be highly expressed in invasive colon and breast carcinoma tissues, and high levels of Girdin expression correlate significantly with ErbB2 oncogene expression in breast cancer (Garcia-Marcos et al, 2011;Jiang et al, 2008;Ling et al, 2011). Interestingly, ErbB2 expression is also transcriptionally regulated by AP-2α and is associated with AP-2α in breast cancer (Allouche et al, 2008;Bosher et al, 1995;Pellikainen et al, 2004).…”
Section: Biological Implications Of the Par-3-ap-2-girdin Pathway In mentioning
confidence: 99%
“…These findings raise the possibility that regulation of cell polarization by the PAR-3-AP-2α-Girdin pathway might be impaired in cells that lose expression of these proteins during prostate cancer progression. Girdin has been reported to be highly expressed in invasive colon and breast carcinoma tissues, and high levels of Girdin expression correlate significantly with ErbB2 oncogene expression in breast cancer (Garcia-Marcos et al, 2011;Jiang et al, 2008;Ling et al, 2011). Interestingly, ErbB2 expression is also transcriptionally regulated by AP-2α and is associated with AP-2α in breast cancer (Allouche et al, 2008;Bosher et al, 1995;Pellikainen et al, 2004).…”
Section: Biological Implications Of the Par-3-ap-2-girdin Pathway In mentioning
confidence: 99%
“…Next we asked whether TAT-GIV-CT peptides can exogenously modulate complex, multireceptor driven cellular phenotypes previously attributed to full length GIV, e.g., cell migration (8,9) (Fig. 3 A-C) and tumor cell invasion through basement membrane during cancer metastasis (10) (Fig. 3 D-F).…”
Section: Cell-permeable Giv-ct Peptides Are Effective In Exogenous Momentioning
confidence: 99%
“…Work from other groups indicated that GIV (also known as girdin) enhances Akt signaling (15) and plays a critical role in cell migration via its interaction with Akt and the actin cytoskeleton (16). GIV was shown to be required for cancer metastasis in murine models by virtue of its ability to control cell migration and actin remodeling (17). We subsequently found that active G␣ i3 , like GIV, promotes Akt signaling, remodeling of the actin cytoskeleton, and tumor cell migration (18).…”
mentioning
confidence: 99%
“…We identified the GEF motif of GIV based on its sequence homology with the synthetic GEF peptide KB-752 (19) and showed that mutational disruption of the ability of GIV to activate G␣ i subunits via this motif abolished the enhanced Akt activation (15), actin cytoskeleton remodeling (16,17,20), and cell migration (16,17) seen in metastatic tumor cells (11).…”
mentioning
confidence: 99%