An activatable near-infrared molecular reporter for fluoro-photoacoustic imaging of liver fibrosis

Miao, Minqian; Miao, Jia; Zhang, Yuan; Zhang, Jinglin; She, Meng Ting; Zhao, Min; Miao, Qingqing; Li, Yang; Zhou, Kailong; Li, Qing

doi:10.1016/j.bios.2023.115399

Cited by 12 publications

(7 citation statements)

References 58 publications

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“…The limitations of this method, such as poor tissue penetration of the light excitation and emission, light scattering, and autofluorescence from biological systems, should be considered in further developing of responsive fluorescence probes for GGT. Interestingly, recent studies have demonstrated the bi- (or multi-) modal probes, such as fluorescence-PA and fluorescence-Raman probes for precise and accurate measurement of GGT activity in vitro and in vivo. Therefore, the development of bi- (or multi-) modal probes would be more preferable in future studies. For the development of almost all responsive probes, the GGT-catalyzed cleavage of γ-glutamyl linker is the sensing mechanism, and this cleavage reaction generally takes a few minutes to hours.…”

Section: Discussionmentioning

confidence: 99%

Section: Measuring Ggt By a Small-molecule-based Responsive Fluoresce...mentioning

confidence: 99%

“…102 Complementary with fluorescence measurements, a fluorescence-PA bimodal imaging probe (IP, Probe #38) for GGT activity was reported by Miao and colleagues (Figure 23). 88 The IP was developed by coupling GGT-responsive γ-glutamyl to thioxanthene-hemicyanine, the NIR fluorophore, and PA contrast agent. An integrin-targeted peptide (cRGD) was also linked to thioxanthene-hemicyanine through a click reaction for targeting of the liver fibrosis region.…”

Section: Measuring Ggt By Other Techniquesmentioning

confidence: 99%

“…Measuring the activity of GGT has also been achieved by alternative techniques, including bioluminescence, chemiluminescence, photoacoustic imaging (PAI), Raman, , ionizing-radiation-based techniques, like positron emission tomography (PET), − and magnetic resonance imaging (MRI). , In comparison with the responsive probes used for fluorescence measurements, the availability of probes employing these techniques for GGT measurements is limited. In this section, advances in the development of probes using these alternative techniques are summarized.…”

Section: Measuring Ggt By a Small-molecule-based Responsive Fluoresce...mentioning

confidence: 99%

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Advances and Perspectives of Responsive Probes for Measuring γ-Glutamyl Transpeptidase

Zhang,

et al. 2023

ACS Meas. Sci. Au

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Gamma-glutamyltransferase (GGT) is a plasma-membrane-bound enzyme that is involved in the γ-glutamyl cycle, like metabolism of glutathione (GSH). This enzyme plays an important role in protecting cells from oxidative stress, thus being tested as a key biomarker for several medical conditions, such as liver injury, carcinogenesis, and tumor progression. For measuring GGT activity, a number of bioanalytical methods have emerged, such as chromatography, colorimetric, electrochemical, and luminescence analyses. Among these approaches, probes that can specifically respond to GGT are contributing significantly to measuring its activity in vitro and in vivo. This review thus aims to highlight the recent advances in the development of responsive probes for GGT measurement and their practical applications. Responsive probes for fluorescence analysis, including "off−on", near-infrared (NIR), two-photon, and ratiometric fluorescence response probes, are initially summarized, followed by discussing the advances in the development of other probes, such as bioluminescence, chemiluminescence, photoacoustic, Raman, magnetic resonance imaging (MRI), and positron emission tomography (PET). The practical applications of the responsive probes in cancer diagnosis and treatment monitoring and GGT inhibitor screening are then highlighted. Based on this information, the advantages, challenges, and prospects of responsive probe technology for GGT measurement are analyzed.

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Section: Discussionmentioning

confidence: 99%

Section: Measuring Ggt By a Small-molecule-based Responsive Fluoresce...mentioning

confidence: 99%

Section: Measuring Ggt By Other Techniquesmentioning

confidence: 99%

Section: Measuring Ggt By a Small-molecule-based Responsive Fluoresce...mentioning

confidence: 99%

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Advances and Perspectives of Responsive Probes for Measuring γ-Glutamyl Transpeptidase

Zhang,

et al. 2023

ACS Meas. Sci. Au

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“…FL/PA imaging developed rapidly because of its good sensitivity and spatial resolution. − Hemicyanine (HCy) is a kind of near-infrared (NIR) organic dye with excellent optical properties. Up to now, a variety of HCy-based probes have been widely exploited for activatable bioimaging and treatment. − In our previous work, an alkaline phosphatase-activated self-assembled HCy nanoparticle was applied for tumor-targeting PA imaging and photothermal therapy .…”

mentioning

confidence: 99%

Tumor-Targeted Fluorescent/Photoacoustic Imaging of Legumain Activity In Vivo

Wang,

Tao,

Zhu

et al. 2023

ACS Sens.

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An Activatable Phototheranostic Probe for Anti‐hypoxic Type I Photodynamic‐ and Immuno‐Therapy of Cancer

Zhao,

Zhang,

Miao

et al. 2023

Advanced Materials

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Photodynamic therapy (PDT), which utilizes type I photoreactions, has great potential as an effective cancer treatment because of its hypoxia‐tolerant superiority over the commonly used type II pathway. A few type I photosensitizers have been exploited; however, they majorly induce cytotoxicity and possess poor tumor specificity and low‐efficient theranostics. To resolve this issue, we herein report an aminopeptidase N (APN)‐activated type I phototheranostic probe (CyA) for anti‐hypoxic PDT in conjunction with immunotherapy for effective cancer treatment. CyA can specifically activate near‐infrared fluorescence, photoacoustic signals, and phototoxicity following APN‐induced substrate cleavage and the subsequent generation of active phototheranostic molecules (such as CyBr). CyA endows specific imaging capabilities and effective phototoxicity towards tumor cells overexpressing APN under both normoxia and hypoxia. In addition, the locally activatable PDT induces systemic antitumor immune responses. More importantly, the integration of localized activated PDT and systemic immunotherapy evokes enhanced therapeutic effects with improved tumor inhibition efficiency in live mice compared with individual treatments. This study aims to present an activatable phototheranostic probe for effective hypoxia‐tolerant PDT and combination therapy.This article is protected by copyright. All rights reserved

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An activatable near-infrared molecular reporter for fluoro-photoacoustic imaging of liver fibrosis

Cited by 12 publications

References 58 publications

Advances and Perspectives of Responsive Probes for Measuring γ-Glutamyl Transpeptidase

Advances and Perspectives of Responsive Probes for Measuring γ-Glutamyl Transpeptidase

Tumor-Targeted Fluorescent/Photoacoustic Imaging of Legumain Activity In Vivo

An Activatable Phototheranostic Probe for Anti‐hypoxic Type I Photodynamic‐ and Immuno‐Therapy of Cancer

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