An Active Role for the Cumulus Oocyte Complex During Ovulation.

Alvino, E.; Robker, Rebecca L.; Russell, Darryl L.

doi:10.1093/biolreprod/81.s1.51

Cited by 1 publication

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“…The precise mechanisms behind this phenotype are unknown, although it has been suggested that expansion may promote the detachment of COCs from granulosa cells in preparation for ovulation, as well as providing a semi‐solid mass to assist in propulsion of the COC from the follicle (Chen et al, ). It has also been demonstrated that cumulus cells from expanded, pre‐ovulatory mouse COCs are more adherent to extracellular matrices such as collagen, found in the follicle wall, and may have proteolytic activity, thus actively participating in their own release from the follicle (Alvino, ).…”

Section: The Hexosamine Biosynthesis Pathwaymentioning

confidence: 99%

The effect of peri‐conception hyperglycaemia and the involvement of the hexosamine biosynthesis pathway in mediating oocyte and embryo developmental competence

Frank

Sutton‐McDowall

Gilchrist

et al. 2014

Molecular Reproduction Devel

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SUMMARYThe environment that the oocyte is exposed to during the peri-conception period can have a significant impact on oocyte developmental competence (the ability of the oocyte to support fertilisation and subsequent embryo development) and the longterm health of the resulting offspring. This is particularly true for maternal hyperglycaemia. While maternal hyperglycaemia during early pregnancy through term development has been extensively studied, the effects on the oocyte itself, and the underlying mechanisms, remain largely unknown. There is increasing evidence, however, for the role of the fuel-sensing hexosamine biosynthesis pathway in mediating the effects of hyperglycaemia in many different cell types. In this review, we will focus on the reproductive consequences of maternal hyperglycaemia during the peri-conceptual period and the role of the hexosamine pathway in mediating these processes.Mol. Reprod. Dev. 81: 391À408,

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Section: The Hexosamine Biosynthesis Pathwaymentioning

confidence: 99%