Carbon capture and storage (CCS) is a critical technology for mitigating greenhouse gas emissions and combating climate change. CCS involves capturing CO2 emissions from industrial processes and power plants and injecting them deep underground for long-term storage. The success of CCS projects is influenced by various factors, including the regional pressure dissipation effects in subsurface geological formations. The safe and efficient operation of CCS projects depends on maintaining the pressure in the storage formation. Regional pressure dissipation, often resulting from the permeability and geomechanical properties of the storage site, can have significant effects on project integrity. This paper provides a state-of-art of the impact of regional pressure dissipation on CCS projects, highlights its effects, and discusses ongoing investigations in this area based on different case studies. The results corroborate the idea that the Sleipner project has considerable lateral hydraulic connectivity, which is evidenced by pressure increase ranging from <0.1 MPa in case of an uncompartmentalized reservoir to >1 MPa in case of substantial flow barriers. After five years of injection, pore pressures in the water leg of a gas reservoir have increased from 18 MPa to 30 MPa at Salah project, resulting in a 2 cm surface uplift. Furthermore, artificial CO2 injection was simulated numerically for 30 years timespan in the depleted oil reservoir of Jurong, located near the Huangqiao CO2-oil reservoir. The maximum amount of CO2 injected into a single well could reach 5.43 × 106 tons, potentially increasing the formation pressure by up to 9.5 MPa. In conclusion, regional pressure dissipation is a critical factor in the implementation of CCS projects. Its impact can affect project safety, efficiency, and environmental sustainability. Ongoing research and investigations are essential to improve our understanding of this phenomenon and develop strategies to mitigate its effects, ultimately advancing the success of CCS as a climate change mitigation solution.