An Acute Large Pericardial Effusion in a Scleroderma Renal Crisis

Ghallab, Muhammad; Abosheaishaa, Hazem; Rasool, Muhammad Haseeb ul; Noff, Nicole C; Miller, Daniel; Alashry, Mahmoud; Hosna, Asma; Collura, Giovina

doi:10.7759/cureus.41897

Cited by 1 publication

(1 citation statement)

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“…Pericardial involvement in scleroderma occurs clinically in 5-16% of cases, and cardiac involvement is generally associated with a poor prognosis [16]. The rapid formation of pericardial effusion with a tamponade effect that occurred in this case may have been due not only to renal failure but also to the reduced elasticity and distensibility of the fibrotic pericardium.…”

Section: Discussionmentioning

confidence: 74%

Thrombotic Microangiopathy and Multiple Organ Failure in Scleroderma Renal Crisis: A Case Report

Aterini,

Gallo,

Vadalà

et al. 2023

Cureus

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This case report can be considered a rare occurrence of scleroderma renal crisis (SRC) presenting with a severe clinical course and multiple organ failure. A patient diagnosed with systemic sclerosis four years earlier was admitted to the hospital because of severe malignant systolic-diastolic arterial hypertension and acute kidney injury (AKI). Exacerbating disease suggested thrombotic microangiopathy (TMA) and the PLASMIC (Platelet count; combined hemoLysis variable; absence of Active cancer; absence of Stem-cell or solid-organ transplant; MCV; INR; Creatinine) score was used in the differential diagnosis. Despite the timely initiation of therapy with ACE inhibitors (ACE-I), the progressive renal failure required hemodialysis treatment, but renal function never recovered. Disease duration, skin involvement, and previous specific pharmacological therapy represented multiple risk factors that determined a clinical course complicated by pericardial tamponade with acute heart failure, acute pancreatitis, and ischemic stroke, with fatal evolution. These complications presented a challenging clinical sequence of events requiring an interdisciplinary course of action. Timely ascertainment of the SRC is important given the possible severe organ involvement as well as mortality. A diagnosis of scleroderma renal crisis should be considered in cases of acute kidney injury associated with known risk factors. Early treatment and collaboration between rheumatology and renal physicians can improve patient outcomes.

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Section: Discussionmentioning

confidence: 74%