An adaptation of the Korean mini-mental state examination (K-MMSE) in elderly Koreans: Demographic influence and population-based norms (the AGE study)

Han, Changsu; Jo, Sangmee Ahn; Jo, Inho; Kim, Eunkyung; Park, Moon Ho; Kang, Yeonwook

doi:10.1016/j.archger.2007.08.012

Cited by 257 publications

(233 citation statements)

References 27 publications

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“…It is important to point out that age is a determining factor for cognitive decline. Results demonstrate that of the six 80-year old or older elderly individuals in this study, 66.6% presented with cognitive decline, which is congruent with another study demonstrating similar data (11) .…”

Section: Discussionsupporting

confidence: 81%

Estado cognitivo e condições de saúde de idosos que participam de grupos de convivência

Leite

Hildebrandt

Kirchner

et al. 2012

Rev. Gaúcha Enferm.

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The objective of the present study was to identify the cognitive and health conditions of elderly participants in community center groups in a northern city in Rio Grande do Sul. The study is a descriptive cross-sectional research, performed with 85 elderly participants attending community center groups. Two instruments were used for data collection. One instrument gathered sociodemographic data and included the Mini-Mental State Examination (MMSE). Descriptive statistics were used in data analysis. Results indicated a female predominance 79(92.9%), with 52 participants within the age bracket 60-69 years (61.2%); 46 were widowed (54.1%), 45 had four to seven years of formal education (52.9%) and 53 were living with companions (62.4%). Hypertension and varicose veins, in addition to fall events 34(40%) stood out among the diseases/conditions determined to affect participants in this study. The MMSE demonstrated that 20(23.6%) of the elderly people presented with cognitive decline. Results point out the need for guided interventions to maintain functional capacity and autonomy in the elderly.Descriptors: Aged. Cognition. Recreation and Leisure Activities Centers. RESUMO Objetivou-se identificar o estado cognitivo e as condições de saúde de idosos participantes de grupos de convivência de um município do norte do Rio Grande do Sul. Pesquisa transversal e descritiva, realizada com 85 idosos participantes de grupos de convivência. Foram utilizados dois instrumentos para a coleta dos dados. Um contém dados sociodemográficos e o Miniexame do Estado Mental (MEEM). Para a análise dos dados

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Section: Discussionsupporting

confidence: 81%

Estado cognitivo e condições de saúde de idosos que participam de grupos de convivência

Leite

Hildebrandt

Kirchner

et al. 2012

Rev. Gaúcha Enferm.

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“…As expected, and as demonstrated in previous studies (Gallacher et al, 1999;Han et al, 2008;Moraes et al, 2010), these results confirm that the MMSE score increases as the educational level increases and decreases as age progresses. There are fewer studies that have focused on other sociodemographic variables and the respective results are rather controversial.…”

Section: Discussionsupporting

confidence: 78%

“…Older age has been found to significantly increase the probability of obtaining lower scores, whereas the worst performance has been found among those with lower education levels, and ceiling effects have been observed among highly educated individuals (Anderson, Sachdev, Brodaty, Trollor, & Andrews, 2007;Bravo & Hébert, 1997;Gallacher et al, 1999;Matallana et al, 2011;Moraes, Pinto, Lopes, Litvoc, & Bottino, 2010). The magnitude of the effect of education level is so strong that the education is invariably considered a criterion for the establishment of normative-data for the MMSE (Han et al, 2008;Mathuranath et al, 2007;Measso et al, 1993). Previous studies regarding gender have proved to be more controversial; only few found a significant association between this variable and cognitive screening tests performance (Mías, Sassi, Masih, Querejeta, & Krawchik, 2007;Ribeiro, Oliveira, Cupertino, Neri, & Yassuda, 2010;Scazufca, Almeida, Vallada, Tasse, & Menezes, 2009).…”

Section: Introductionmentioning

confidence: 99%

The Relevance of Sociodemographic and Health Variables on MMSE Normative Data

Freitas

Simões

Alves

et al. 2014

Applied Neuropsychology: Adult

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The Mini-Mental State Examination (MMSE) is the most broadly used cognitive screening instrument in clinical and research contexts. The MMSE was administered to a community-based sample of cognitively healthy adults (n=850), stratified according to several sociodemographic variables, with a distribution similar to that observed in the Portuguese population. This study aimed to analyse the influence of sociodemographic (age, gender, educational level, marital and employment status, geographic region, geographic localisation, and residence area) and health variables (subjective memory complaints of the participant and evaluated by the informant, depressive symptoms and family history of dementia) on the subjects' performance on the MMSE and to establish normative data for the Portuguese population. Educational level and age significantly contributed to the prediction of the MMSE scores, explaining 26% of its variance.Regarding health variables, only the subjective memory complaints of the participant showed a small contribution (4%) to the variance of the MMSE scores. According to these results, age and education were considered in the development of the normative data of the MMSE for the Portuguese population.

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“…Patients were registered between November 2001 and January 2012. Subjects were eligible for this clinical trial only if they satisfied all following criteria: All patients were diagnosed as AD or probable AD according to the standards of the NINCDS-ADRDA (National Institute of Neurological and Communicative Disorders and StrokeAlzheimer's Disease and Related Disorders Association) [13]; They had a score of 26 or less in the Korean version of the MiniMental State Examination (K-MMSE) [14]; They had a history of cognitive decline which was gradual in onset and progressive for more than 6 months; they had a reliable caregiver who helped them to take their medication, participate in the assessment, and provide ongoing information about them [13]. Patients were excluded if any of the following conditions was present: other neurodegenerative diseases except AD (i. e., Parkinson's disease or Huntington's disease), psychiatric disorder or severe behavioral disturbances requiring psychotropic medications, cerebral injuries induced by trauma, hypoxia, and/or ischemia, clinically active cerebrovascular disease, medical history of seizure disorder, and other physical conditions requiring acute treatments.…”

Section: Subjectsmentioning

confidence: 99%

Association of the Choline Acetyltransferase Gene with Responsiveness to Acetylcholinesterase Inhibitors in Alzheimer’s Disease

et al. 2015

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Introduction: The response to acetylcholinesterase inhibitors (AChEIs) of Alzheimer?s disease (AD) patients varies depending on the genetic characteristics of the patient. We have examined the association of response to AChEIs and genetic polymorphisms in AD patients. Methods: 158 patients with AD underwent treatment with AChEIs, and the therapeutic effect was assessed with the Korean version of the Mini Mental State Examination (K-MMSE). The association of 25 SNPs located in 3 genes (CHAT, CHT and ACHE) with changes in the K-MMSE score was analyzed. Results: The response to AChEIs in AD patients was significantly associated with 2 SNPs on the intronic region of CHAT rs2177370 (uncorrected P=0.0025, FDR controlled P=0.026) and rs3793790 (uncorrected P=0.0024, FDR controlled P=0.026). Conclusion: The results of our study confirmed again that genetic polymorphism of CHAT has an influence on drug response in AD.

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An adaptation of the Korean mini-mental state examination (K-MMSE) in elderly Koreans: Demographic influence and population-based norms (the AGE study)

Cited by 257 publications

References 27 publications

Estado cognitivo e condições de saúde de idosos que participam de grupos de convivência

Estado cognitivo e condições de saúde de idosos que participam de grupos de convivência

The Relevance of Sociodemographic and Health Variables on MMSE Normative Data

Association of the Choline Acetyltransferase Gene with Responsiveness to Acetylcholinesterase Inhibitors in Alzheimer’s Disease

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