In order to improve the efficiency of parameter adjustment in aerodynamic configuration design of flight vehicle, the influences of the main configuration parameters on the aerodynamic coefficients, dynamic coefficients and dynamic characteristic parameters are analyzed based on the integrated design concept and parameter sensitization analysis method. A new idea of aerodynamic optimization taking the dynamic characteristic parameters as the objectives is proposed, and the major configuration parameters are optimized based on the idea and immune clonal selection algorithm. damping coefficient M , etc. For the thrust vector control flight vehicles, there are thrust vector transfer coefficient to flight vehicle K MT and thrust vector coefficient to attack angle K T . Expressions of the aerodynamic characteristic parameters are shown in table 2. 2 2 z z z z M m V SL a J J 2 2 z z z z z z M m VSL a J J 2 2 z z z z z z M m V SL a J J zT