An addition to the controversy on sunlight exposure and melanoma risk: A meta-analytical approach

Nelemans, Patty J.; Rampen, F.H.J.; Ruiter, Dirk J.; Verbeek, A.L.M.

doi:10.1016/0895-4356(95)00032-1

Cited by 73 publications

(46 citation statements)

References 46 publications

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“…Several case-control and cohort studies have investigated the association between individual sun exposure and melanoma risk. Meta-analyses of these studies show consistent results [65,75,76,178] that continue to be supported by the results of studies published after the meta-analyses were undertaken [112]. There is strong evidence that an intermittent pattern of sun exposure increases melanoma risk.…”

Section: Sun Exposurementioning

confidence: 59%

Melanoma Epidemiology and Prevention

Berwick

Buller

Cust

et al. 2015

Cancer Treatment and Research

122

121

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The epidemiology of melanoma is complex, and individual risk depends on sun exposure, host factors, and genetic factors, and in their interactions as well. Sun exposure can be classified as intermittent, chronic, or cumulative (overall) exposure, and each appears to have a different effect on type of melanoma. Other environmental factors, such as chemical exposures-either through occupation, atmosphere, or food-may increase risk for melanoma, and this area warrants further study. Host factors that are well known to be important are the numbers and types of nevi and the skin phenotype. Genetic factors are classified as

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Section: Sun Exposurementioning

confidence: 59%

Melanoma Epidemiology and Prevention

Berwick

Buller

Cust

et al. 2015

Cancer Treatment and Research

122

121

View full text Add to dashboard Cite

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“…Direct measures of cumulative, chronic sun exposure might have been an exposure of interest. However, this is very difficult to measure and some previous studies with such information have not found strong associations with melanoma risk (21). Because we restricted analysis to Caucasians, the results may not be generalizable to other racial groups, although melanoma is relatively rare in other races (22).…”

Section: Discussionmentioning

confidence: 81%

Risk Factors for Melanoma by Body Site

Cho

Rosner

Colditz

2005

Cancer Epidemiology, Biomarkers &Amp; Prevention

193

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It has been hypothesized that cutaneous melanoma at different anatomic sites develops through divergent pathways. We examined this hypothesis prospectively. We followed 152,949 women and 25,204 men free of cancer at baseline for up to 14 years in three large prospective studies. We examined risk factors for melanoma by anatomic location (head or neck, trunk, upper extremity, and lower extremity). Polytomous logistic regression was used to test the difference among risk factors by location of melanoma. A total of 511 incident cases of invasive melanoma (49 head or neck, 188 trunk, 98 upper extremity, and 176 lower extremity) were included in the analysis. Compared with females, males had a higher risk of developing melanoma on the head or neck and trunk. History of severe and painful sunburn was most strongly related to melanoma of upper extremity; individuals with >10 burns had a 6.86-fold (95% confidence interval, 2.62-18.00) higher risk of melanoma of upper extremity compared with those with no burns (P for trend < 0.0001; P for difference by body site = 0.04). Number of moles was most strongly related to melanoma of the trunk; the multivariate relative risk for having >10 moles was 4.67 (95% confidence interval, 3.07-7.11) compared with having no moles (P for trend < 0.0001; P for difference by body site = 0.04). Age, family history of melanoma, and hair color did not statistically differ by anatomic site of the cancer. These data support divergent etiologic pathways of melanoma development by anatomic sites.

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“…It is not possible with the data available to answer this question with any certainty. However, a large number of epidemiologic studies have been conducted on the relationship between solar UV exposure and melanoma, and these have been summarized quantitatively by Nelemans et al (28) and Elwood and Jopson (2). Combining the highest reported levels of ''intermittent'' exposure produced a summary OR for all studies of 1.71 (95% CI, 1.54-1.90) in the Elwood study, and 1.57 (95% CI, 1.29-1.91) for populationbased studies in the Nelemans investigation.…”

Section: Discussionmentioning

confidence: 99%

Tanning Beds, Sunlamps, and Risk of Cutaneous Malignant Melanoma

Gallagher

Spinelli

Lee

2005

Cancer Epidemiology, Biomarkers &Amp; Prevention

210

141

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Background: A number of studies have been conducted evaluating the risk of cutaneous malignant melanoma after exposure to sunlamps and/or sunbeds. The proportion of subjects in the individual studies who have reported exposure has, in general, been modest, and the resulting risk estimates for melanoma have been unstable with wide 95% confidence intervals (95% CI). The inconclusive results seen in individual studies have resulted in confusion as to the carcinogenicity of these devices. Methods: We conducted a systematic review and metaanalysis of these studies. A review of the literature from Jan 1, 1984 to April 2004 using MEDLINE identified 12 casecontrol studies and 1 cohort study which quantitatively evaluated the use of sunlamps and/or sunbeds and subsequent melanoma. After applying exclusion/inclusion criteria, 9 case-control and 1 cohort study provided data for the analysis. Summary odds ratios (OR) and 95% CIs for sunlamp/

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An addition to the controversy on sunlight exposure and melanoma risk: A meta-analytical approach

Abstract: The following full text is a publisher's version. For additional information about this publication click this link.

Cited by 73 publications

References 46 publications

Melanoma Epidemiology and Prevention

Melanoma Epidemiology and Prevention

Risk Factors for Melanoma by Body Site

Tanning Beds, Sunlamps, and Risk of Cutaneous Malignant Melanoma

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