An additional case of neutrophilic dermatosis histopathologically mimicking <i>Cryptococcus</i> in a patient with Sweet's syndrome

Byekova, Yevgeniya A.; Shedd, Angela D.; Schiro, James A.; Barrett, Terry L.; Lewin, Marc R.

doi:10.1111/cup.12407

Cited by 13 publications

(15 citation statements)

References 4 publications

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“…Recently, a unique histological presentation of Sweet's syndrome has been described which mimics cutaneous cryptococcosis. Only six cases have been reported to date in the literature . We report two further cases of neutrophilic dermatosis that were initially histopathologically concerning for cryptococcosis.…”

Section: Introductionmentioning

confidence: 89%

Cryptococcoid Sweet's syndrome: Two reports of Sweet's syndrome mimicking cutaneous cryptococcosis

2017

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Section: Introductionmentioning

confidence: 89%

Cryptococcoid Sweet's syndrome: Two reports of Sweet's syndrome mimicking cutaneous cryptococcosis

2017

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“…Eight cases describing the histological findings of capsule‐like vacuolated spaces mimicking Cryptococcus exist in the literature, all in the setting of neutrophilic dermatoses, and the term “cryptoccoid Sweet syndrome” has been coined . Ko et al described three cases of neutrophilic dermatoses, two in severely ill patients who ultimately succumbed to their disease .…”

Section: Discussionmentioning

confidence: 99%

“…syndrome" has been coined. [5][6][7][8][9] Ko et al described three cases of neutrophilic dermatoses, two in severely ill patients who ultimately succumbed to their disease. 6 Byekova et al reported a case of a patient with clinical and pathological findings suspicious for Cryptococcus ultimately deemed to have Sweet syndrome who suffered a rapidly fatal clinical course similar to our first patient.…”

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confidence: 99%

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Cryptococcus‐like changes in the setting of vasculitis

et al. 2018

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Cutaneous vasculitis has many underlying causes, and the clinical and histological findings often overlap. Inflammatory vasculitis can mimic infection; however, distinction is critical for the timely institution of appropriate therapy. We present two patients who had generalized polymorphous eruptions whose cutaneous pathology showed vasculitis with unusual haloed yeast‐like cells within the inflammatory infiltrate, mimicking Cryptococcus. The unusual cells stained negatively with Gomori methenamine silver and periodic acid‐Schiff fungal stains, but positively for CD68 and had cytoplasmic reactivity with antibody to myeloperoxidase (MPO). Both patients had positive serum anti‐MPO antibodies. The first patient experienced a rapidly fatal course, whereas the second patient improved with prompt initiation of systemic corticosteroids. Interestingly, the second case had prior biopsy showing Sweet syndrome with crypotoccoid‐appearing cells. Cryptococcoid cells have been described previously in association with neutrophilic dermatoses, but not in the setting of vasculitis as was seen in our patients. Our cases add to the existing literature on crypotoccoid mimickers, and are the first to be reported in association with vasculitis.

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“…Ultimately, after transmission electron microscopy, these histological findings were found to be compatible with degrading neutrophils. In 2014, Byekova et al described an additional case. Most recently, a report by Wilson et al detailed 2 cases of Sweet syndrome mimicking cutaneous Cryptococcus and proposed the term “cryptococcoid Sweet's syndrome” for these cases.…”

Section: Discussionmentioning

confidence: 99%

Cryptococcal cellulitis: A rare entity histologically mimicking a neutrophilic dermatosis

2017

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Cutaneous Cryptococcus infection presents classically with granulomatous and gelatinous reactive patterns. Cases mimicking neutrophilic dermatoses have not been described. Conversely, neutrophilic dermatoses with degrading cells mimicking cryptococcal organisms have been reported. We report a case of cryptococcal cellulitis in an immunocompromised male with a robust neutrophilic infiltrate raising histologic consideration for a neutrophilic dermatosis.

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An additional case of neutrophilic dermatosis histopathologically mimicking Cryptococcus in a patient with Sweet's syndrome

Cited by 13 publications

References 4 publications

Cryptococcoid Sweet's syndrome: Two reports of Sweet's syndrome mimicking cutaneous cryptococcosis

Cryptococcoid Sweet's syndrome: Two reports of Sweet's syndrome mimicking cutaneous cryptococcosis

Cryptococcus‐like changes in the setting of vasculitis

Cryptococcal cellulitis: A rare entity histologically mimicking a neutrophilic dermatosis

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