An Address ENTITLED SOME CLINICAL FACTS REGARDING MAMMARY CANCER

Cameron, Hector Charles

doi:10.1136/bmj.1.2514.577

Cited by 18 publications

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“…In one patient, axillary disease recurred two and a half years later, but even then Halsted found nothing in the breast. Two years after Halsted's report Cameron [2] recommended ipsilateral mastectomy for axillary adenocarcinoma with no apparent involvement of the breast, and this became the standard treatment for some time, justified by the fact that cancer was often discovered in the gland after it had been removed [3].…”

Section: Introductionmentioning

confidence: 99%

Clinical experience with axillary presentation breast cancer

Galimberti

Bassani

Monti

et al. 2004

Breast Cancer Res Treat

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We present our experience of 50 cases of occult primary tumours presenting as axillary metastases, all with histological report of adenocarcinoma compatible with mammary carcinoma. After bilateral US and mammography, with MRI and mammoscintigraphy where necessary, ipsilateral breast cancer was suspected in 23 cases and quadrantectomy performed. Breast cancer was found only in 12 (24%). In the other 27 women there was no clinical or instrumental suspicion of breast cancer or other primary disease site, so the main treatment was complete axillary dissection plus radiotherapy to the ipsilateral breast (given to all patients). Chemotherapy alone was given to 27 patients, hormone treatment to 5 patients, and both to 18. Mean follow-up is 41.3 months (range 108-1). Thirty-nine (84%) patients are alive with no evidence of disease, two are alive with breast disease, five patients have died of metastatic disease (with no evidence breast disease). Our experience, like that of the literature, confirms that the breast should be extensively investigated but that blanket investigations are not usually revealing. We present guidelines for the work-up of patients presenting with axillary disease.

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Section: Introductionmentioning

confidence: 99%

Clinical experience with axillary presentation breast cancer

Galimberti

Bassani

Monti

et al. 2004

Breast Cancer Res Treat

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“…Beginning in 1909, the recommended treatment was a blind radical or modified mastectomy, based on the assumption that the surgical specimen would contain the primary tumor. 8 As the overall role of surgery in breast cancer management has evolved to less invasive procedures, breast preservation has been increasingly proposed as an alternative to blind mastectomy, using radiotherapy to eradicate the occult disease. 9 -11 In 1990, Ellerbroek and colleagues 12 published a clinical study examining outcomes in patients diagnosed with axillary metastasis from an unknown primary.…”

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confidence: 99%

Feasibility of Breast Preservation in the Treatment of Occult Primary Carcinoma Presenting With Axillary Metastases

et al. 2001

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“…Prolonged survival in malignant disease is well recognized (Cameron, 1909;Sutton, 1961), and a state of partial immunity has been suggested to exist in such patients (Boyd, 1921): the fibrous reaction may be tangible evidence of this.…”

Section: Discussionmentioning

confidence: 99%

Cardiac Failure in Malignant Disease

Taylor¹

1965

Thorax

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An Address ENTITLED SOME CLINICAL FACTS REGARDING MAMMARY CANCER

Cited by 18 publications

References 0 publications

Clinical experience with axillary presentation breast cancer

Clinical experience with axillary presentation breast cancer

Feasibility of Breast Preservation in the Treatment of Occult Primary Carcinoma Presenting With Axillary Metastases

Cardiac Failure in Malignant Disease

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