1998
DOI: 10.1002/(sici)1099-1077(199803)13:2<121::aid-hup961>3.0.co;2-b
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An adenylate cyclase inhibitor in the treatment of excited psychosis

Abstract: The authors examined the advantage of addition of the adenylate cyclase inhibitor demeclocycline (DMC) versus placebo to haloperidol therapy in the treatment of excited psychosis. Sixteen manic or excited schizoaective patients completed a double-blind controlled ®ve week trial. Nine patients were assigned to DMC and haloperidol and seven patients were assigned to placebo and haloperidol. Brief Psychiatric Rating Scale (BPRS) was used as an assessment tool at baseline, 1, 2, 3, 4 and 5 weeks. BPRS scores showe… Show more

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Cited by 6 publications
(2 citation statements)
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“…In this hypothesis, schizophrenia patients have excessive dopaminergic activity that may be the underlying cause of schizophrenia (Seeman, 1987). The brains of schizophrenic patients have increased levels of adenylate cyclase activity (Memo et al, 1983;Kerwin and Beats, 1990), and there is evidence that indicates adenylate cyclase inhibitors may have a therapeutic role in the treatment of excited psychosis (Roitman et al, 1998). The switch of the CB 1 receptor back to G␣ i/o coupling under persistent D 2 receptor activation may be the brain's compensatory attempt to ablate the increase in adenylate cyclase activity in the schizophrenic brain.…”
Section: Discussionmentioning
confidence: 82%
“…In this hypothesis, schizophrenia patients have excessive dopaminergic activity that may be the underlying cause of schizophrenia (Seeman, 1987). The brains of schizophrenic patients have increased levels of adenylate cyclase activity (Memo et al, 1983;Kerwin and Beats, 1990), and there is evidence that indicates adenylate cyclase inhibitors may have a therapeutic role in the treatment of excited psychosis (Roitman et al, 1998). The switch of the CB 1 receptor back to G␣ i/o coupling under persistent D 2 receptor activation may be the brain's compensatory attempt to ablate the increase in adenylate cyclase activity in the schizophrenic brain.…”
Section: Discussionmentioning
confidence: 82%
“…4 Both effects imply the potential importance of AC inhibition as a mode of preventing heart failure. AC inhibitors may also be potentially used for treatment of cancer, 5 psychosis, 6 and for the purposes of contraception or treatment of male infertility. 7,8 ACs contain 12 transmembrane helices, and two intracellular lobes generally referred to as C 1 and C 2 .…”
Section: Introductionmentioning
confidence: 99%