As a major indicator of Obstructive Sleep Apnea Syndrome (OSAS) in clinical diagnosis, the monitoring of sleep apnea plays an important role in medical treatments of modern society. This paper proposes a portable sleep apnea monitoring system, which is of high-precision and low-power consumption, and capable of performing the long-term monitoring of OSAS patients multiple physiological parameters in clinical treatments. In the system, the AC modulated detection is adopted, and low amplification ratios are utilized in forestage and a high-resolution AD converter is designed in post-stages. Thus, it is able to acquire, analyze, and process physiological signals in real-time. In addition, ultralow-power chips are used in control system to save the power consumption. The experimental results show that our monitoring system has the strengths of high stability, low-power consumption (peak current90mA), and strong anti-interference ability, which demonstrates the potential in practical applications.