An adolescent boy with takotsubo cardiomyopathy after <scp>COVID</scp>‐19 vaccination

Oguri, Saori; Maeda, Tomoki; Kishimoto, Shintaro; Kondo, Hidekazu; Ihara, Kenji

doi:10.1111/ped.15321

Cited by 1 publication

(3 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Of the 19 patients from the included studies, 13 [2][3][4][5][6][7][8][9]11,12,14,16,17 of them adhere to the established diagnostic criteria of TTS according to the diagnostic algorithm of TTS published by the European Heart Journal in 2018, 27 but the remaining may need further cardiac tests to confirm the diagnosis. Three patients presented with typical clinical symptoms of TTS and had typical apical ballooning of the left ventricle by echocardiography or ventriculography, but lacking CMR to exclude acute myocarditis given the presence of corresponding red flags such as fever 15,19 or elevated c-reactive protein.…”

Section: Discussionmentioning

confidence: 99%

“…An increasing number of studies have reported takotsubo syndrome (TTS) development in the setting of vaccination. [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] TTS triggered by vaccines is extremely rare, and published literature available so far is limited to case reports. There is no large-scale systematic review examining the association between vaccines and TTS.…”

Section: Introductionmentioning

confidence: 99%

“…While vaccines, regardless of the underlying mechanism, are considered safe and highly effective in infectious disease prevention, 1 their cardiac side effects have caught the public eye. An increasing number of studies have reported takotsubo syndrome (TTS) development in the setting of vaccination 2–19 . TTS triggered by vaccines is extremely rare, and published literature available so far is limited to case reports.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Takotsubo syndrome and vaccines: a systematic review

Li,

Peddibhotla

et al. 2024

ESC Heart Failure

View full text Add to dashboard Cite

AimsTakotsubo syndrome (TTS) is a rare complication of vaccination. In this study, we sought to provide insight into the characteristics of reported TTS induced by vaccination.Methods and resultsWe did a systematic review, searching PubMed, Embase, Web of Science, Ovid MEDLINE, Journals@Ovid, and Scopus databases up to 26 April 2023 to identify case reports or case series of vaccine‐induced TTS. We then extracted and summarized the data from these reports. Eighteen reports were identified, with a total of 19 patients with TTS associated with vaccinations. Of the 19 included patients, the majority were female (n = 13, 68.4%) with a mean age of 56.6 ± 21.9 years. Seventeen patients developed TTS after coronavirus disease 2019 vaccination, 14 of whom received an mRNA vaccination. Two cases of TTS occurred after influenza vaccination. Among the 19 patients, 17 (89.5%) completed transthoracic echocardiography and 16 (84.2%) underwent angiography procedures. Seven patients (36.8%) completed cardiac magnetic resonance imaging. The median time to symptom onset was 2 (inter‐quartile range, 1–4) days. The most common symptoms were chest pain (68.4%), dyspnoea (57.9%), and digestive symptoms (31.6%). A total of 57.9% of patients developed nonspecific symptoms such as fatigue, myalgia, diaphoresis, and fever. Among the 16 reported cases of TTS, 15 patients (93.8%) exhibited elevated cardiac troponin levels, while among the nine reported cases, eight patients (88.9%) had elevated natriuretic peptide levels. All patients had electrocardiographic changes: ST‐segment change (47.1%), T‐wave inversion (58.8%), and prolonged corrected QT interval (35.3%). The most common TTS type was apical ballooning (88.2%). Treatment during hospitalization typically included beta‐blockers (44.4%), angiotensin‐converting enzyme inhibitors/angiotensin receptor blockers (33.3%), and diuretics (22.2%). After treatment, 81.3% of patients were discharged with improved symptoms. Among this group, nine patients (56.3%) were reported to have recovered ventricular wall motion during follow‐up. Two patients (12.5%) died following vaccination without resuscitation attempts.ConclusionsTTS is a rare but potentially life‐threatening complication of vaccination. Typical TTS symptoms such as chest pain and dyspnoea should be considered alarming symptoms, though nonspecific symptoms are common. The risks of such rare adverse events should be balanced against the risks of infection.

show abstract